Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Haijun, M; Xiaohui, Z; Ting, M; Renner, W; Abulizi, P; Baopeng, T.
Association between KCNE1 (G38S) genetic polymorphism and non-valvular atrial fibrillation in an Uygur population.
Wien Klin Wochenschr. 2012; 124(21-22):737-741
Doi: 10.1007/s00508-012-0245-7
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Renner Wilfried
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- Abstract:
- The relationship between KCNE1 G38S genetic polymorphism and non-valvular atrial fibrillation is different among different populations. The study explored the KCNE1 G38S to understand if the KCNE1 G38S is associated with the Uygur atrial fibrillation patients. KCNE1 G38S genetic polymorphism was determined between 237 non-valvular atrial fibrillation cases and 237 control subjects using PCR-RFLP. In univariate analyses, there was a statistical difference in genotype distribution between the patients and controls, and a significant difference in allele frequency of KCNE1 G38S was observed between the two groups (62.6 vs 52.7 %, p = 0.003). In multivariate analyses, the KCNE1 38G variant was independently associated with a significant predisposing effect on AF after adjusting for related risk factors, and the odds ratio for patients was 1.634 (95 % CI: 1.192-2.240, p = 0.002). The KCNE1 38G is a risk factor for incident AF in an Uygur population. The KCNE1 G38S might have different impact on AF in different ethnicities.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Atrial Fibrillation - ethnology
- Atrial Fibrillation - epidemiology
- Female -
- Genetic Predisposition to Disease - ethnology
- Heart Valve Diseases - ethnology
- Humans -
- Male -
- Polymorphism, Single Nucleotide - genetics
- Potassium Channels, Voltage-Gated - genetics
- Prevalence -
- Risk Factors -
- Find related publications in this database (Keywords)
- Atrial fibrillation
- KCNE1 gene
- Uygur ethnicity
- Han ethnicity