Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Wilinska, ME; Chassin, LJ; Schaller, HC; Schaupp, L; Pieber, TR; Hovorka, R.
Insulin kinetics in type-I diabetes: continuous and bolus delivery of rapid acting insulin.
IEEE TRANS BIOMED ENG. 2005; 52(1): 3-12. Doi: 10.1109/TBME.2004.839639
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Pieber Thomas; Schaupp Lukas
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: We investigated insulin lispro kinetics with bolus and continuous subcutaneous insulin infusion (CSII) modes of insulin delivery. Seven subjects with type-1 diabetes treated by CSII with insulin lispro have been studied during prandial and postprandial conditions over 12 hours. Eleven alternative models of insulin kinetics have been proposed implementing a number of putative characteristics. We assessed 1) the effect of insulin delivery mode, i.e., bolus or basal, on the insulin absorption rate, the effects of 2) insulin association state and 3) insulin dose on the rate of insulin absorption, 4) the remote insulin effect on its volume of distribution, 5) the effect of insulin dose on insulin disappearance, 6) the presence of insulin degradation at the injection site, and finally 7) the existence of two pathways, fast and slow, of insulin absorption. An iterative two-stage parameter estimation technique was used. Models were validated through assessing physiological feasibility of parameter estimates, posterior identifiability, and distribution of residuals. Based on the principle of parsimony, best model to fit our data combined the slow and fast absorption channels and included local insulin degradation. The model estimated that 67(53-82)% [mean (interquartile range)] of delivered insulin passed through the slow absorption channel [absorption rate 0.011(0.004-0.029) min(-1)] with the remaining 33% passed through the fast channel [absorption rate 0.021(0.011-0.040) min(-1)]. Local degradation rate was described as a saturable process with Michaelis-Menten characteristics [VMAX = 1.93(0.62 - 6.03) mU min(-1), KM = 62.6(62.6 - 62.6) mU]. Models representing the dependence of insulin absorption rate on insulin disappearance and the remote insulin effect on its volume of distribution could not be validated suggesting that these effects are not present or cannot be detected during physiological conditions.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Algorithms -; Computer Simulation -; Diabetes Mellitus, Type 1 - blood; Drug Therapy, Computer-Assisted - methods; Feasibility Studies - methods; Female - methods; Humans - methods; Insulin - administration and dosage; Insulin Infusion Systems - administration and dosage; Kinetics - administration and dosage; Male - administration and dosage; Models, Biological - administration and dosage; Reproducibility of Results - administration and dosage; Sensitivity and Specificity - administration and dosage; Treatment Outcome - administration and dosage
Find related publications in this database (Keywords): biological systems modeling; identification; insulin kinetics; parameter estimation; type-1 diabetes