Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoffmann, KM; Grillitsch, M; Deutschmann, A; Högenauer, C; Stojakovic, T; Hauer, AC.
Serum macromolecular creatine kinase type 1 as a diagnostic clue in inflammatory bowel disease?
Eur J Pediatr. 2013; 172(5):699-701
Doi: 10.1007/s00431-013-1935-5
(- Case Report)
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hoffmann Karl Martin
- Co-Autor*innen der Med Uni Graz
- Aschenbrenner Marlene
- Deutschmann Andrea
- Hauer Almuthe
- Hoegenauer Christoph
- Stojakovic Tatjana
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- Abstract:
- In adults, macromolecular creatine kinase (CK) type 1 has been linked to ulcerative colitis (UC), but not to Crohn's disease (CD). We present two patients with pediatric inflammatory bowel disease (IBD) in which macrocreatine kinase (macro-CK) type 1 led to the final diagnosis of UC. A 13 year old with bloody diarrhea and weight loss was diagnosed with CD. CK elevation was interpreted as perimyocarditis attributed to CD. CK elevation persisted; however, cardiac evaluation remained unremarkable. CK gel electrophoresis revealed macro-CK type 1. During a disease flare-up and reevaluation (endoscopy and histology), the diagnosis was changed to UC. A 12-year-old girl with bloody diarrhea, weight loss, and anemia was diagnosed with CD (patchy distal colitis and aphtoid lesions). Repeated CK elevation was observed. Gel electrophoresis confirmed macro-CK type 1. After reevaluation during a flare-up (endoscopy and histology), the diagnosis was changed to UC. Conclusion CK elevation in pediatric IBD could suggest macro-CK type 1 formation, which is possibly linked to UC. In a subset of IBD patients, macro-CK type 1 could help differentiate UC from CD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Biological Markers - blood
- Child -
- Creatine Kinase - blood
- Diagnosis, Differential -
- Female -
- Gastrointestinal Hemorrhage - diagnosis
- Humans -
- Inflammatory Bowel Diseases - diagnosis Inflammatory Bowel Diseases - pathology
- Find related publications in this database (Keywords)
- Inflammatory bowel disease
- Creatine kinase
- Macro-CK type 1
- Ulcerative colitis
- Children