Medizinische Universität Graz - Research portal
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SHR Neuro Cancer Cardio Lipid Metab Microb
Prager, W; Rappl, T.
Phase IV study comparing incobotulinumtoxinA and onabotulinumtoxinA using a 1:1.5 dose-conversion ratio for the treatment of glabellar frown lines.
J Cosmet Dermatol. 2012; 11(4):267-271
Doi: 10.1111/jocd.12001
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Rappl Thomas
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- Abstract:
- Background IncobotulinumtoxinA and onabotulinumtoxinA are effective treatments for glabellar frown lines, and a dose of 20 U is recommended for both preparations. However, debate continues over using the same dosages of these products, although a 1:1 dose ratio has been proven in several head-to-head clinical trials in neurological and esthetic indications. Objectives To investigate whether a 50% higher dose of onabotulinumtoxinA was nonsuperior to incobotulinumtoxinA in the treatment of glabellar frown lines in the short and long term. Methods and materials Subjects aged 1865 years with symmetrical moderate-to-severe glabellar frown lines (score: =2 on a validated Merz 5-point scale) at maximum frown were enrolled. Corrugator muscles on both sides were treated with two injections of either 4 U incobotulinumtoxinA or 6 U onabotulinumtoxinA (equivalent to 20 and 30 U, respectively, if corrugator muscles on both sides and the procerus are treated) allowing intra-individual comparison. Glabellar frown line severity was assessed from standardized photographs every 4 weeks for 4 months and, in a subset of subjects, for up to 6 months posttreatment. The primary efficacy endpoint was the percentage of subjects with an improvement of =1 point on the 5-point scale at week 4. Nonsuperiority was assessed by comparing the response rates of each product. Results Nonsuperiority of a 50% higher dose of onabotulinumtoxinA to that of incobotulinumtoxinA was confirmed at 4 weeks, 4 months, and 6 months posttreatment. Conclusion There is generally no reason to increase the dose of either incobotulinumtoxinA or onabotulinumtoxinA above the 20 U recommended for glabellar frown lines.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Botulinum Toxins, Type A - administration & dosage
- Eyebrows -
- Facial Muscles - drug effects
- Female -
- Forehead -
- Humans -
- Male -
- Middle Aged -
- Neuromuscular Agents - administration & dosage
- Skin Aging - drug effects
- Find related publications in this database (Keywords)
- glabellar lines
- botulinum toxin
- wrinkles