Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Tzankov, A; Dirnhofer, S; Beham-Schmid, C.
Normal bone marrow and common reactive alterations].
Pathologe. 2012; 33(6):496-507
Doi: 10.1007/s00292-012-1649-x
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Beham-Schmid Christine
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- Abstract:
- Histological examination of bone marrow biopsies is an important and powerful diagnostic tool to assess various hematological and non-hematological disorders. Morphological examination of such biopsies requires knowledge of the composition of normal bone marrow and its variations, such as age-related changes. Diagnostic problems may arise due to poor specimen quality, insufficient sections or stainings and insufficient experience with reactive bone marrow changes which occasionally resemble neoplastic disorders. Reactive bone marrow processes can affect one or more hematopoietic cell lines, lead to disruption of the normal architecture and specifically affect the bone marrow stroma. Optimal bone marrow diagnosis requires adequately stained slides and, when needed, immunophenotyping and molecular examinations. Furthermore, rather than biopsy interpretation of other organs, pathologists routinely need clinical history information for correct interpretation and diagnosis of bone marrow changes. In this article, the normal features of bone marrow as well as the most frequent reactive bone marrow alterations are described.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Biopsy, Needle -
- Bone Marrow - pathology
- Bone Marrow Cells - pathology
- Bone Marrow Diseases - genetics
- Bone Marrow Examination - methods
- Cell Count -
- Child -
- Child, Preschool -
- Diagnosis, Differential -
- Hematopoietic Stem Cells - pathology
- Humans -
- Immunohistochemistry -
- Infant -
- Leukemia - genetics
- Lymphoma - genetics
- Middle Aged -
- Molecular Diagnostic Techniques -
- Necrosis -
- Primary Myelofibrosis - genetics
- Reference Values -
- Young Adult -
- Find related publications in this database (Keywords)
- Bone marrow
- Reactive Alterations
- Staining
- Immunophenotyping
- Molecular examinations