Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Krause, R; Valentin, T; Salzer, H; Hönigl, M; Valentin, A; Auner, H; Zollner-Schwetz, I.
Which lumen is the source of catheter-related bloodstream infection in patients with multi-lumen central venous catheters?
Infection. 2013; 41(1):49-52
Doi: 10.1007/s15010-012-0391-x
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Krause Robert
- Co-Autor*innen der Med Uni Graz
- Hönigl Martin
- Salzer Helmut J. F.
- Valentin Thomas
- Zollner-Schwetz Ines
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- Abstract:
- Purpose Paired blood cultures, drawn from the catheter and a peripheral vein, used for calculation of the differential time to positivity (DTP), have been proposed for the detection of catheter-related bloodstream infections (CRBSIs). The most relevant catheter lumen to be sampled in multi-lumen central venous catheters (CVCs) has not been recommended. Methods Forty-four febrile neutropaenic patients, following haematopoietic stem cell transplantation (HSCT) and with multi-lumen CVCs in place, were investigated using the DTP method of blood samples drawn from every lumen of the CVC and a peripheral vein. Results Twelve of 44 patients (27 %) had CRBSIs, as determined by the DTP method. In 10 of 12 (83 %) febrile neutropaenic patients, after HSCT, CRBSIs originated from the CVC lumen used for parenteral nutrition and blood products only. 17 % had CREST originating from the other CVC lumen (p = 0.039). Conclusion In most patients, CRBSIs originated from the CVC lumen used for parenteral nutrition and blood products, indicating that this lumen is the main source of CREST. However, since 17 % of patients had CRBSIs originating from another lumen, each lumen of multi-lumen CVCs has to be considered as a potential source of CREST and should, ideally, be sampled in order to avoid failure in diagnostic procedures.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Bacteremia - diagnosis
- Catheter-Related Infections - diagnosis
- Central Venous Catheters - adverse effects
- Female -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Male -
- Middle Aged -
- Neutropenia -
- Find related publications in this database (Keywords)
- Catheter-related bloodstream infection
- Blood cultures
- Stem cell transplantation