Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoenigl, M; Krause, R.
Antifungal therapy of aspergillosis of the central nervous system and aspergillus endophthalmitis.
Curr Pharm Des. 2013; 19(20):3648-3668
Doi: 10.2174/13816128113199990342
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Co-Autor*innen der Med Uni Graz
- Krause Robert
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- Abstract:
- Cerebral Aspergillosis is the most lethal manifestation of infection due to Aspergillus species arising most commonly as hematogenous dissemination from a pulmonary focus, direct extension from paranasal sinus infection or direct inoculation through trauma and surgery of the central nervous system (CNS). Voriconazole is currently considered the standard of treatment of CNS aspergillosis with liposomal amphotericin B being the next best alternative. Neurosurgical resection of infected cerebral tissue in addition to antifungal therapy is frequently performed in patients with CNS aspergillosis to prevent neurological deficits and improve outcome. Aspergillus endophthalmitis may occur endogenously mostly from a pulmonary focus or exogenously following eye surgery or trauma. Although amphotericin B is still described as the primary therapy, voriconazole is increasingly considered the first line treatment of Aspergillus endophthalmitis. Vitrectomy is recommended in most cases of Aspergillus endophthalmitis.
- Find related publications in this database (using NLM MeSH Indexing)
- Amphotericin B - therapeutic use
- Animals -
- Antifungal Agents - therapeutic use
- Aspergillosis - drug therapy
- Aspergillus - isolation & purification
- Combined Modality Therapy -
- Endophthalmitis - drug therapy
- Eye Infections, Fungal - drug therapy
- Humans -
- Neuroaspergillosis - drug therapy
- Pyrimidines - therapeutic use
- Triazoles - therapeutic use
- Vitrectomy - methods
- Find related publications in this database (Keywords)
- Aspergillus
- invasive aspergillosis
- endophthalmitis
- central nervous system
- CNS infection
- blood brain barrier
- CSF levels
- tissue levels
- voriconazole
- posaconazole
- amphotericin B
- liposomal amphotericin B
- echinocandin
- itraconazole
- epidemiology
- surgery
- surgical
- neurosurgical
- vitrectomy
- intravitreal