Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Kienreich, K; Rutters, F; de Jongh, R; van Ballegooijen, AJ; Grübler, M; Tomaschitz, A; Dekker, JM.
Role of vitamin D in the development of insulin resistance and type 2 diabetes.
Curr Diab Rep. 2013; 13(2):261-270
Doi: 10.1007/s11892-012-0358-4
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Pilz Stefan
- Co-Autor*innen der Med Uni Graz
- Grübler Martin
- Kienreich Katharina
- Tomaschitz Andreas
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- Abstract:
- Vitamin D deficiency is mainly a consequence of insufficient sunlight induced vitamin D production in the skin and has been associated with various chronic diseases including type 2 diabetes. Experimental data have shown that vitamin D is important for glucose induced insulin secretion, improves insulin resistance, and exerts anti-inflammatory actions. Epidemiological studies have largely documented that a poor vitamin D status is associated with higher risk of insulin resistance and type 2 diabetes. The majority of randomized controlled trials (RCTs) in healthy or prediabetic individuals have, however, failed to demonstrate relevant vitamin D effects on insulin resistance or diabetes incidence. In patients with type 2 diabetes, a few RCTs reported some moderate effects of vitamin D on glycemic control and insulin resistance. While these findings warrant further in-depth studies, the current evidence is insufficient to recommend vitamin D supplementation for the prevention or treatment of type 2 diabetes.
- Find related publications in this database (using NLM MeSH Indexing)
- Diabetes Mellitus, Type 2 - drug therapy
- Diabetes Mellitus, Type 2 - etiology
- Diabetes Mellitus, Type 2 - prevention & control
- Humans -
- Insulin Resistance - physiology
- Vitamin D - metabolism
- Vitamin D - therapeutic use
- Vitamin D Deficiency - complications
- Find related publications in this database (Keywords)
- Vitamin D
- Cholecalciferol
- Insulin resistance
- Diabetes
- Glucose metabolism