Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Rauchenwald, M; Bauernhofer, T; De Santis, M; Füreder, T; Höltl, W; Kramer, G; Krause, S; Loidl, W; Oismüller, R; Reissigl, A; Schmeller, N; Stackl, W; Stoiber, F; Krainer, M.
Treatment of castration refractory Prostate cancer.
Wien Klin Wochenschr. 2012; 124(15-16):538-551 Doi: 10.1007/s00508-012-0206-1
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Bauernhofer Thomas
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Within the last two years the therapy of castration resistant prostate cancer (CRPC) has made major advances. Both the COU-AA-301 phase III trial and the TROPIC trial showed a survival benefit for patients after docetaxel failure treated with abiraterone or cabazitaxel, respectively. With rising interest for chemotherapeutic options and novel drugs, our goal was to review within the context of a multidisciplinary team the available evidence and explore the standards for medical treatment of prostate cancer outside of clinical trials. From this background, we are carefully evaluating the current treatment recommendations, based on the available evidence, and highlight potential future treatment options but also discuss important clinical topics like treatment until progression versus the advantage of chemo holidays and definition of particular patient subgroups. Additionally, we focus on novel molecular entities, which will most likely be available in the near future, such as MDV3100 and Sipuleucel T. The role and importance of palliation with radiotherapy and proactive medical management of pain is also discussed, as well as new options for bone directed therapy. The multitude of treatment options for patients with advanced prostate cancer clearly asks for a close collaboration between urologists, medical oncologists and radiation therapists.
Find related publications in this database (using NLM MeSH Indexing): Castration -; Drug Therapy - standards; Humans -; Male -; Practice Guidelines as Topic -; Prostatic Neoplasms - therapy; Radiotherapy, Adjuvant - standards; Treatment Failure -