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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Rabusin, M; Snowden, JA; Veys, P; Quartier, P; Dalle, JH; Dhooge, C; Di Bartolomeo, P; Gonzalez-Vicent, M; Gibson, B; Iriondo, A; Juergens, H; Lisukov, I; Messina, C; Mialou, V; Steward, CG; Urban, C; Renard, M; Giurici, N; Peters, C; Badoglio, M; Ronfani, L; Dini, G; Farge, D; Saccardi, R; European Group for Blood and Marrow Transplantation Autoimmune Diseases and Paediatric Disease Working Parties.
Long-term outcomes of hematopoietic stem cell transplantation for severe treatment-resistant autoimmune cytopenia in children.
Biol Blood Marrow Transplant. 2013; 19(4):666-669
Doi: 10.1016/j.bbmt.2012.12.008
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- Co-authors Med Uni Graz
- Urban Ernst-Christian
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- Abstract:
- We analyzed the long-term outcomes of pediatric patients registered in the European Group for Blood and Marrow Transplantation database who underwent hematopoietic stem cell transplantation (HSCT) for severe treatment refractory autoimmune cytopenia. With a median follow-up of 100 months, event-free survival was 54% overall, with no significant difference between allogeneic HSCT (n = 15) and autologous HSCT (n = 7) recipients (58% versus 42%; P = .50). Despite a trend toward failure of response or relapse after autologous HSCT compared with allogeneic HSCT, the difference was not significant (43% versus 13%; P = .30). Treatment-related mortality was high in both HSCT groups (29% and 16%; P = .09). Based on the limited numbers of subjects in this retrospective analysis, both allogeneic and autologous HSCT may induce complete and persistent responses in approximately one-half of pediatric patients with severe refractory autoimmune cytopenia, although treatment-related toxicity is high.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Autoimmune Diseases - immunology
- Child -
- Child, Preschool -
- Female -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Infant -
- Male -
- Neutropenia - immunology
- Recurrence -
- Retrospective Studies -
- Survival Analysis -
- Thrombocytopenia - immunology
- Transplantation, Autologous -
- Transplantation, Homologous -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Refractory cytopenia
- HSCT
- Allogeneic transplant
- Evans syndrome
- Childhood