Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Strenger, V; Feierl, G; Resch, B; Zarfel, G; Grisold, A; Masoud-Landgraf, L; Dosch, V; Riedl, R; Zenz, W; Müller, W; Urlesberger, B.
Fecal carriage and intrafamilial spread of extended-spectrum β-lactamase-producing enterobacteriaceae following colonization at the neonatal ICU.
Pediatr Crit Care Med. 2013; 14(2):157-163
Doi: 10.1097/PCC.0b013e31824ea2a2
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Strenger Volker
- Co-Autor*innen der Med Uni Graz
- Feierl Gebhard
- Grisold Andrea
- Masoud-Landgraf Lilian
- Müller Wilhelm
- Resch Bernhard
- Riedl Regina
- Urlesberger Berndt
- Zarfel Gernot
- Zenz Werner
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- Abstract:
- Fecal carriage of extended-spectrum β-lactamase-producing enterobacteriaceae may contribute to the spread of extended-spectrum β-lactamase-producing enterobacteriaceae into the community. The objective of this study was to assess the duration of fecal carriage after discharge and the occurrence of intrafamilial transmission. Case series. Quaternary care children's hospital. Patients colonized with extended-spectrum β-lactamase-producing enterobacteriaceae at the neonatal ICU and the respective household members. Screening for intestinal extended-spectrum β-lactamase-producing enterobacteriaceae colonization was done at 1, 2, 4, 6, 9, and 12 months after discharge. Genetic relatedness of isolated extended-spectrum β-lactamase-producing enterobacteriaceae strains was determined using automated rep-PCR. Twenty-five neonates (case-patients) colonized with extended-spectrum β-lactamase-producing enterobacteriaceae (one extended-spectrum β-lactamase-Escherichia coli; six extended-spectrum β-lactamase-Klebsiella pneumoniae; 11 extended-spectrum β-lactamase-Klebsiella oxytoca; and seven extended-spectrum β-lactamase-Serratia marcescens) were included. Duration of fecal carriage was longer (up to 1 yr) in case-patients colonized with Klebsiella species than in case-patients colonized with Serratia marcescens (<4 months). During follow-up, strains and species of extended-spectrum β-lactamase-producing enterobacteriaceae different from the primary strain were found in four and three case-patients, respectively. In nine of 49 (18.4%) included household members, extended-spectrum β-lactamase-producing enterobacteriaceae were found during the follow-up period. In two of nine colonized household members, the isolated extended-spectrum β-lactamase-producing enterobacteriaceae was identical to the primary strains of the respective case-patients. After intestinal colonization with extended-spectrum β-lactamase-producing enterobacteriaceae at the neonatal ICU, infants potentially remain carriers during the first year after discharge. Intrafamilial spread has been proven.
- Find related publications in this database (using NLM MeSH Indexing)
- Carrier State - microbiology
- Cross Infection - microbiology
- Enterobacteriaceae - genetics Enterobacteriaceae - metabolism
- Enterobacteriaceae Infections - microbiology Enterobacteriaceae Infections - transmission
- Escherichia coli - genetics Escherichia coli - isolation & purification
- Family -
- Feces - microbiology
- Female -
- Humans -
- Infant -
- Infant, Newborn -
- Intensive Care Units, Neonatal -
- Klebsiella oxytoca - genetics Klebsiella oxytoca - isolation & purification
- Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification
- Male -
- Serratia marcescens - genetics Serratia marcescens - isolation & purification
- Time Factors -
- beta-Lactamases - biosynthesis
- Find related publications in this database (Keywords)
- antibiotic resistance
- colonization
- neonatal ICU
- transmission