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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Longo, C; Casari, A; Pepe, P; Moscarella, E; Zalaudek, I; Argenziano, G; Pellacani, G.
Confocal microscopy insights into the treatment and cellular immune response of Basal cell carcinoma to photodynamic therapy.
Dermatology. 2012; 225(3):264-270
Doi: 10.1159/000345106
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Zalaudek Iris
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- Abstract:
- Background: Photodynamic therapy (PDT) represents an optimal treatment for basal cell carcinoma (BCC). Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that has been applied in skin oncology and for BCC diagnosis. Moreover, RCM is a useful tool to determine noninvasive treatment efficacy of nonmelanoma skin cancer. Objective: We aimed to investigate the role of RCM in assessing the efficacy of PDT in the treatment of BCC and to evaluate the skin changes following the PDT. Methods: Ten patients with 12 BCCs were treated with PDT. Dermoscopy and RCM imaging were performed at baseline as well as 7 days (T1), 30 days and 18 months after PDT. Cytological examination was taken at baseline and in case of BCC persistence. Results: At T1, RCM showed the presence of several dendritic-shaped cells within the epidermis, corresponding to activated Langerhans cells. After 1 month, RCM showed the persistence of 2 BCCs, which escaped the clinical and dermoscopic diagnosis. At the long-term follow-up, none of the tumors revealed signs of persistence or recurrence. Conclusion: RCM is a valuable noninvasive tool for the diagnosis and treatment monitoring of BCC using PDT. Copyright (C) 2012 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Basal Cell - drug therapy
- Dermoscopy -
- Female -
- Humans -
- Immunity, Cellular - physiology
- Male -
- Microscopy, Confocal - methods
- Middle Aged -
- Photochemotherapy - methods
- Skin Neoplasms - drug therapy
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Basal cell carcinoma
- Reflectance confocal microscopy
- Photodynamic therapy