Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hedberg, M; Nord, CE; ESCMID Study Group on Antimicrobial Resistance in Anaerobic Bacteria.
Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe.
Clin Microbiol Infect. 2003; 9(6):475-488
Doi: 10.1046/j.1469-0691.2003.00674.x
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- Study Group Mitglieder der Med Uni Graz:
- Feierl Gebhard
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- Abstract:
- Objective To evaluate the activity of old and newer antianaerobic drugs against clinical isolates of Bacteroides fragilis group strains from different parts of Europe. Methods Bacteroides fragilis group isolates from 37 laboratories in 19 countries were biochemically characterized. The MICs of seven antimicrobial agents were determined by the agar dilution method as recommended by the NCCLS. Production of beta-lactamase was detected by nitrocefin. Results There were 1284 B. fragilis group isolates included in the study. Abdominal infections and wounds were the most common sources of isolation and B. fragilis was the dominating species. Ninety-nine percent of the strains were resistant to ampicillin (breakpoint 2 mg/L), 6% to cefoxitin (64 mg/L), 15% to clindamycin (8 mg/L) and 9% to moxifloxacin (8 mg/L). Less than 1% were resistant to imipenem (16 mg/L), piperacillin-tazobactam (128 mg/L) and metronidazole (32 mg/L). Ninety-six percent of the isolates were beta-lactamase producers. Conclusion Antimicrobial resistance among the B. fragilis group is increasing.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Bacterial Agents - pharmacology
- Bacteroides fragilis - drug effects
- Bacteroides fragilis -
- Microbial Sensitivity Tests -
- Find related publications in this database (Keywords)
- Bacteroides fragilis group
- antimicrobial resistance
- beta-lactams
- clindamycin
- metronidazole
- moxifloxacin