Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wachowiak, R; Thieltges, S; Rawnaq, T; Kaifi, JT; Fiegel, H; Metzger, R; Quaas, A; Mertens, PR; Till, H; Izbicki, JR; .
Y-Box-binding Protein-1 is a Potential Novel Tumour Marker for Neuroblastoma.
Anticancer Res. 2010; 30(4):1239-1242
Web of Science
PubMed
- Co-authors Med Uni Graz
- Till Holger
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- Abstract:
- Backround: The Y-box-binding protein-1 (YB-1) is a member of a family of DNA-binding proteins and an oncogenic transcription factor that is highly expressed in cancers of the breast, lung and prostate. To date, no data are available on its role in neuroblastoma. The aim of the present study was to evaluate the YB-1 expression in neuroblastoma. Materials and Methods: A tumour tissue microarray (TMA) was constructed from 36 neuroblastoma samples which were analysed by immunohistochemistry for YB-1 expression. Results: Expression of YB-1 was detected in 35 of 37 (94.6%) neuroblastoma cases examined. Nevertheless, no correlation of YB-1 expression with survival, risk factors or stage of the disease was observed. Conclusion: As the majority of neuroblastomas express YB-1, this protein may play an important role in tumour pathogenesis. The results of this study suggest that YB-1 may serve as a novel immune marker for neuroblastoma and may be potentially useful as a therapeutic target.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Nucleus - metabolism
- DNA-Binding Proteins - biosynthesis
- Humans -
- Immunohistochemistry -
- Infant -
- Microarray Analysis -
- Neoplasm Staging -
- Neuroblastoma - metabolism Neuroblastoma - pathology
- Nuclear Proteins - biosynthesis
- Risk Factors -
- Tumor Markers, Biological - biosynthesis
- Y-Box-Binding Protein 1 -
- Find related publications in this database (Keywords)
- Y-box binding protein 1
- YB-1
- neuroblastoma
- immunohistochemistry
- tumour marker