Medizinische Universität Graz - Research portal
Selected Publication:
Till, H; Kellnar, S; Strassburger, CJ; Schwarz, HP; Barretton, G; Joppich, I.
Fetal adrenal transplants respond to ACTH and prevent addisonian crisis in adrenalectomized rats
Pediatr Surg Int. 1998; 13(4):271-273
Doi: 10.1007/s003830050314
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- Leading authors Med Uni Graz
- Till Holger
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- Abstract:
- The present study investigates whether fetal adrenal transplants into the omentum of adrenalectomized rats will be integrated into the recipient's endocrine system to provide competent adrenocortical function. The results demonstrate that fetal adrenals graft with a rich vascular supply, mature histologically, and produce increasing levels of corticosterone. When bilateral adrenalectomy is performed in the recipient, survival is prolonged and addisonian crisis can be prevented. Moreover, adrenocorticotrophic hormone levels decrease with increasing levels of corticosterone, indicating that the fetal grafts are integrated into the physiological pituitary-adrenocortical feedback system.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenal Glands - embryology
- Adrenalectomy -
- Adrenocorticotropic Hormone - blood
- Animals -
- Female -
- Fetal Tissue Transplantation -
- Pituitary-Adrenal System - physiology
- Rats -
- Rats, Inbred Lew -
- Find related publications in this database (Keywords)
- fetal transplantation
- adrenals
- addisonian crises
- rat
- adrenocorticotropic hormone