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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Till, H; Bergmann, F; Metzger, R; Haeberle, B; Schaeffer, K; von Schweinitz, D; Prosst, RL.
Videoscopic fluorescence diagnosis of peritoneal and thoracic metastases from human hepatoblastoma in nude rats
SURG ENDOSC. 2005; 19(11): 1483-1486.
Doi: 10.1007/s00464-005-0316-1
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- Leading authors Med Uni Graz
- Till Holger
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- Abstract:
- Background: Various medical disciplines are employing photodynamic diagnosis (PDD) when searching for malignancies. It is still unknown whether pediatric solid tumors such as hepatoblastorna are susceptible to this technique as well. Methods: Human hepatoblastorna cells were injected into the abdomen or right thoracic cavity of nude rats. Tumor growth was allowed for 7 weeks. Then, photosensitization was induced by peritoneal lavage with 5-aminolevulinic acid (ALA). Applying the Storz PDD system and one 4-mm scope, all animals were investigated by videoscopic white light diagnosis (WD) and PDD. Suspicious lesions were marked and analyzed by spectrometry and histology. Results: Positive fluorescence was documented for every tumor seen by WD in the abdomen or right thoracic cavity. Spectrometry of lesions showed a 6.34-fold increased fluorescence intensity. Histology revealed hepatoblastoma in all specimens. Conclusion: Human hepatoblastoma can be detected by PDD in a rat model. Considering the clinical success of this method in other specialties, our findings indicate that further investigations to evaluate the benefit of PDD for children with hepatoblastoma should be performed.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Fluorescence -
- Hepatoblastoma - diagnosis Hepatoblastoma - secondary
- Humans -
- Laparoscopy - methods
- Liver Neoplasms - pathology
- Neoplasm Transplantation -
- Peritoneal Neoplasms - diagnosis Peritoneal Neoplasms - secondary
- Rats -
- Rats, Nude -
- Thoracic Neoplasms - diagnosis Thoracic Neoplasms - secondary
- Thoracoscopy - methods
- Video Recording -
- Find related publications in this database (Keywords)
- fluorescence diagnosis
- laparoscopy
- thoracoscopy
- hepatoblastoma
- pediatric oncology