Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Fiegel, HC; Kaifi, JT; Quaas, A; Varol, E; Krickhahn, A; Metzger, R; Sauter, G; Till, H; Izbicki, JR; Erttmann, R; Kluth, D.
Lack of Thy1 (CD90) expression in neuroblastomas is correlated with impaired survival
Pediatr Surg Int. 2008; 24(1):101-105 Doi: 10.1007/s00383-007-2033-4
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Till Holger
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Neuroblastoma (NBL) is the most common solid tumor in children. Tumors in advanced stage or with positive risk factors still have a poor prognosis. Thy1 (CD90) is a membrane glycoprotein expressed in thymus, retinal ganglionic cells, and several types of stem cells. The aim of this study was to assess Thy1 expression in NBL and analyze the correlation with clinical outcome. Sixty-three specimens of NBL were stained for Thy1 on a tissue microarray by immunohistochemistry. Fresh frozen tumor tissues were used for RNA isolation, and RT-PCR analysis for Thy1-mRNA expression was performed. Patients' survival data were correlated with Thy1 status using a log rank test and a Cox regression multivariate analysis. Thy1 was expressed on 51 (81%) of the tumors. Kaplan-Meier survival analysis showed a significantly impaired survival in patients with NBL missing Thy1 (P < 0.005 by log-rank test). A multivariate Cox regression showed an independent prognostic value of Thy1 status for overall survival (P < 0.05). In addition, the frequency of events and deaths was significantly higher in the group of patients with Thy1 negative tumors, as assessed by ANOVA analysis (P < 0.05 by F-test). The data showed that Thy1-negative NBL patients have a significantly impaired overall survival compared with Thy1-positive NBL patients. Thus, Thy1 seemed to be a marker with a specific prognostic value in NBL patients. Future studies are aiming at the biological role of this marker in the tumor cell differentiation.
Find related publications in this database (using NLM MeSH Indexing): Antigens, Thy-1 - biosynthesis Antigens, Thy-1 - genetics; Child, Preschool -; Electrophoresis, Agar Gel -; Follow-Up Studies -; Gene Expression Regulation, Neoplastic -; Gene Expression Regulation, Neoplastic - epidemiology; Humans -; Immunohistochemistry -; Infant -; Neoplasm Staging -; Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - mortality; RNA, Neoplasm - genetics; Retrospective Studies -; Reverse Transcriptase Polymerase Chain Reaction -; Survival Rate - trends; Tumor Markers, Biological - biosynthesis Tumor Markers, Biological - genetics
Find related publications in this database (Keywords): neuroblastoma; Thy1; tumor marker; childhood cancer