Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Dimai, HP; Ramschak-Schwarzer, S; Lax, S; Lipp, RW; Leb, G.
Hyperthyroidism of Graves' disease: evidence for only unilateral involvement of the thyroid gland in a 31-year-old female patient.
J Endocrinol Invest. 1999; 22(3):215-219 Doi: 10.1007/BF03343545 (- Case Report)
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Führende Autor*innen der Med Uni Graz: Dimai Hans Peter
Co-Autor*innen der Med Uni Graz: Lipp Rainer
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Abstract:: Hyperthyroidism of Graves' disease (Morbus Basedow) is known to involve the thyroid gland in toto, unlike Graves' ophthalmopathy which clinically may either be unilateral or bilateral. We report a 31-year-old Caucasian female patient who presented with unilateral goiter and clinical and laboratory evidence for hyperthyroidism. High-resolution ultrasonography of the thyroid gland revealed a morphology indicative of an autoimmune thyroid disease strictly limited only to the right lobe. 123I-scintiscanning showed a homogenous but several fold increased uptake of the radionuclide in the right lobe of the thyroid gland, whereas the uptake in the left lobe did not differ from the uptake in normal controls. Cytology of the fine needle aspirate of the right lobe revealed a remarkable inflammatory background mainly by presence of lymphocytes, a finding which was not seen in the cytology of the left lobe. Furthermore, both serum antibodies to TSH-receptors and thyroid peroxidase were significantly increased. Consequently, hyperthyroidism of Graves' disease with the involvement of only one lobe of the thyroid gland was diagnosed.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Antithyroid Agents - therapeutic use; Autoantibodies - blood; Biopsy, Needle - blood; Female - blood; Goiter - blood; Graves Disease - blood; Humans - blood; Iodide Peroxidase - immunology; Methimazole - therapeutic use; Receptors, Thyrotropin - immunology; Thyroglobulin - immunology; Thyroid Gland - pathology; Thyrotropin - blood; Thyroxine - blood; Triiodothyronine - blood
Find related publications in this database (Keywords): Graves Disease; High-Resolution Ultrasonography; Scintiscanning; Fine Needle Aspiration; Antibodies to TSH-Receptor (Trab); Antibodies to Thyroid Peroxidase (Tpoab)