Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Deutschmann, A; Schlagenhauf, A; Leschnik, B; Hoffmann, KM; Hauer, A; Muntean, W.
Increased Procoagulant Function of Microparticles In Pediatric Inflammatory Bowel Disease: Role In Increased Thrombin Generation.
J Pediatr Gastroenterol Nutr. 2013; 56(4):401-407
Doi: 10.1097/MPG.0b013e31827daf72
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Deutschmann Andrea
- Muntean Eugen
- Co-Autor*innen der Med Uni Graz
- Hauer Almuthe
- Hoffmann Karl Martin
- Leschnik Bettina
- Schlagenhauf Axel
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- Abstract:
- Objectives: Patients with inflammatory bowel disease (IBD) have a higher risk for venous thromboembolism compared with non-IBD subjects. The pathogenic mechanisms of the thrombotic events are not fully understood. We investigated levels of circulating microparticles and their influence on thrombin generation in pediatric patients with IBD during active and quiescent disease compared with healthy controls. Methods: Plasma samples were collected from 33 pediatric patients with Crohn disease (CD), 20 pediatric patients with ulcerative colitis (UC), and 60 healthy controls. Microparticles' procoagulant activity was measured by enzyme-linked immunosorbent assay, and the dependency of thrombin generation on microparticles-derived tissue factor was determined by means of calibrated automated thrombography. Results: The procoagulant function of microparticles was significantly increased in patients with active and inactive CD, and active UC compared with controls. Endogenous thrombin potential was significantly higher in patients with CD and UC compared with controls. A minor influence of microparticles on thrombin generation was only observed for patients with active UC. Conclusions: Our study shows increased procoagulant function of microparticles in pediatric patients with active and quiescent CD and active UC compared with controls, but demonstrates that they are not a major cause for the higher thrombin generation in pediatric patients with IBD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adolescent - epidemiology
- Blood Coagulation -
- Blood Coagulation Tests -
- Cell-Derived Microparticles - metabolism
- Child -
- Cohort Studies -
- Colitis, Ulcerative - blood
- Crohn Disease - blood
- Enzyme-Linked Immunosorbent Assay -
- Female -
- Humans -
- Kinetics -
- Male -
- Prothrombin - metabolism
- Risk -
- Severity of Illness Index -
- Thrombin - metabolism
- Thromboplastin - metabolism
- Venous Thromboembolism - epidemiology
- Find related publications in this database (Keywords)
- Crohn disease
- microparticles
- ulcerative colitis
- venous thromboembolism