Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Komericki, P; Akkilic-Materna, M; Strimitzer, T; Weyermair, K; Hammer, HF; Aberer, W.
Oral xylose isomerase decreases breath hydrogen excretion and improves gastrointestinal symptoms in fructose malabsorption - a double-blind, placebo-controlled study.
Aliment Pharmacol Ther. 2012; 36(10):980-987
Doi: 10.1111/apt.12057
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- Führende Autor*innen der Med Uni Graz
- Komericki Peter
- Co-Autor*innen der Med Uni Graz
- Aberer Werner
- Akkilic-Materna Merve
- Hammer Heinz
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- Abstract:
- Background Incomplete resorption of fructose results in increased colonic hydrogen production and is a frequent cause of abdominal symptoms. The only treatment available is diet. Aim To study whether orally administered xylose isomerase (XI), an enzyme that catalyses the reversible isomerisation of glucose and fructose, can decrease breath hydrogen excretion in patients with fructose malabsorption. Methods Patients received 25g fructose in 100mL water together with either placebo or XI capsules. Primary endpoint was the reduction in breath hydrogen excretion, as assessed by the area under the breath hydrogen curve over 4h (AUC). A secondary endpoint was the reduction in abdominal pain, bloating and nausea assessed on a visual analogue scale (VAS, range: 010). A P value ANDlt;0.05 was considered statistically significant. Results Sixty-five patients in whom fructose malabsorption had been diagnosed by positive breath hydrogen test within the previous year, were included in the study [15 males, 50 females; mean age 43.3 (s.d.=14.4), range: 2173years]. The median AUC was 885ppm/240min in the XI group compared to 2071ppm/240min in the placebo group (P=0.00). Median scores for abdominal pain (0.7 vs. 1.3) and nausea (0.2 vs. 0.6), but not for bloating (P=0.053), were significantly improved after XI (P=0.009 and P=0.005) as compared with placebo. Conclusions Oral administration of xylose isomerase significantly decreased breath hydrogen excretion after ingestion of a watery fructose solution. Nausea and abdominal pain were significantly improved by xylose isomerase.
- Find related publications in this database (using NLM MeSH Indexing)
- Abdominal Pain - etiology Abdominal Pain - prevention & control
- Adult -
- Aged -
- Aldose-Ketose Isomerases - administration & dosage
- Area Under Curve -
- Breath Tests -
- Double-Blind Method -
- Female -
- Fructose - adverse effects
- Fructose Intolerance - metabolism Fructose Intolerance - prevention & control
- Gastritis - prevention & control
- Humans -
- Hydrogen - metabolism
- Intestinal Absorption - drug effects
- Male -
- Middle Aged -
- Nausea - etiology Nausea - prevention & control
- Pain Measurement -
- Young Adult -