Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Li, SY; Yang, Z; Gao, YF; Li, GY; Wang, HP; Hinghofer-Szalkay, HG; .
Ligustrazine and the Contractile Properties of Soleus Muscle in Hindlimb-Unloaded Rats.
Aviat Space Environ Med. 2012; 83(11):1049-1054
Doi: 10.3357/ASEM.3249.2012
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Hinghofer-Szalkay Helmut
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- LI S, YANG Z, GAO Y, LI G, WANG H, HINGHOFER-SZALKAY HG. Lingustrazine and the contractile properties of soleus muscle in hindlimb-unloaded rats. Aviat Space Environ Med 2012; 83:1049-54. Background: In this study we investigated the effects of different dosages of ligustrazine (tetramethylpyrazine, Tmp) on soleus function and sarco(endo)plasmatic reticulum Ca2+-ATPase (SERCA) activity in 14-d hindlimb-unloaded (HU) rats. Methods: Female Sprague-Dawley rats were randomly divided into 4 groups (8 rats in each group): synchronous control (CON); HU plus intragastric water instillation (HU-W); HU plus different dosages of instilled Tmp (high: 42.53 mg . kg(-1), HU-TmpH; low: 21.15 mg . kg(-1), HU-TmpL). Muscle contraction force was examined in the soleus muscle. SERCA activity was assayed according to the released inorganic phosphate content. Results: As expected, in HU-W, soleus peak twitch tension (Pt), peak tetanic tension (P-0), time to 50% peak tension (TP50), time to peak tension (TPT), time from peak tension to 50% relaxation (RT50), and SERCA activity decreased, all compared with CON. HU-TmpH Pt and P-0 values were 179% and 90% above HU-W, and 187% and 124% above HU-W in HU-TmpL, respectively. TP50 and TPT values were 148% and 80% slower than HU-W with HU-TmpH and 95% and 32% in the HU-TmpL group, respectively. RT50 was slower than HU-W by 21% in HU-TmpH; SERCA activity elevated by 56% with HU-TmpH and by 72% with HU-TmpL. Conclusions: Ligustrazine may alleviate the decrease of muscle contractile force and increase of shortening velocity in atrophied soleus, possibly by means of elevated sarcoplasmic reticulum Ca2+-ATPase activity.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Dose-Response Relationship, Drug -
- Drinking -
- Eating -
- Female -
- Hindlimb Suspension - physiology
- Kidney - enzymology
- Liver - enzymology
- Lung - enzymology
- Muscle Contraction - drug effects
- Muscle, Skeletal - drug effects
- Myocardium - enzymology
- Platelet Aggregation Inhibitors - administration & dosage
- Pyrazines - administration & dosage
- Rats -
- Rats, Sprague-Dawley -
- Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
- Find related publications in this database (Keywords)
- disuse atrophy
- tail-suspension
- tetramethylpyrazine
- muscle function
- Ca2+-ATPase