Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jimenez-Boj, E; Stamm, TA; Sadlonova, M; Rovensky, J; Raffayová, H; Leeb, B; Machold, KP; Graninger, WB; Smolen, JS.
Rituximab in psoriatic arthritis: an exploratory evaluation.
Ann Rheum Dis. 2012; 71(11):1868-1871
Doi: 10.1136/annrheumdis-2012-201897
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Graninger Winfried
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- Abstract:
- Current therapies for psoriatic arthritis (PsA) comprise synthetic drugs and tumour necrosis factor inhibitors. In contrast, other biologicals including rituximab (RTX) are available for treating rheumatoid arthritis (RA). RTX is effective in autoantibody positive RA patients, although some efficacy has been reported in seronegative individuals. RTX has not yet been assessed in PsA. Therefore, an open label study of RTX in PsA was performed. Nine patients with PsA and 14 with RA received RTX at 1000 mg twice within 14 days and were evaluated over 6 months. A PsA response criteria response was attained in 56% of patients. DAS28 improved from 6.2 to 4.9 (medians) in PsA and 6.4 to 5.2 in RA, and Health Assessment Questionnaire from 1.5 to 1.0 and from 2.1 to 1.4, respectively (all p≤0.05). Disease Activity index for PSoriatic Arthritis changed from 52.0 to 32.5 (p<0.05); C reactive protein and Psoriasis Area and Severity Index did not change significantly. RTX was tolerated well. In this exploratory open study, RTX exhibited significant efficacy in PsA patients with long-standing disease. Thus, RTX may have efficacy in PsA warranting a randomised controlled clinical trial.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies, Monoclonal, Murine-Derived - therapeutic use
- Antirheumatic Agents - therapeutic use
- Arthritis, Psoriatic - drug therapy Arthritis, Psoriatic - pathology Arthritis, Psoriatic - physiopathology
- Female -
- Humans -
- Hyperalgesia - drug therapy Hyperalgesia - pathology Hyperalgesia - physiopathology
- Joints - drug effects Joints - pathology Joints - physiopathology
- Male -
- Middle Aged -
- Pilot Projects -
- Rituximab -
- Treatment Outcome -