Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rieger-Ziegler, V; Rieger, E; Kränke, B; Aberer, W.
Hymenoptera venom allergy: time course of specific IgE concentrations during the first weeks after a sting.
Int Arch Allergy Immunol. 1999; 120(2):166-168
Doi: 10.1159/000024235
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Aberer Werner
- Kränke Birger
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- Abstract:
- Detection of IgE antibodies specific to honeybee or Vespula venoms is an important criterium firstly for the diagnosis of sensitization and secondly for the indication for a specific immunotherapy. Some authors recommend to postpone blood analysis after an insect sting for a certain time because circulating IgE antibodies might be consumed by the allergic reaction, which would result in a false-negative test outcome. We investigated IgE concentrations during the first weeks after an insect sting in 31 patients with an unequivocal history of an anaphylactic reaction after a honeybee (n = 13) or Vespula (n = 18) sting. Blood samples for analysis of specific IgE concentrations (CAP system, Pharmacia Diagnostics, Sweden) were collected within 2 weeks and 5+/-2 weeks after the insect sting. 12/13 patients with honeybee venom and 14/18 patients with Vespula venom sensitization had CAP classes 1 or higher within the first 2 weeks. Those 5 patients with CAP class 0 within the first 2 weeks had detectable IgE concentrations a few weeks later. We conclude that testing for specific IgE to hymenoptera venoms is in most cases useful even during the first 2 weeks after the hymenoptera sting. This allows early decisions on further diagnostic procedures and the therapeutic way to choose. Patients with no detectable IgE should, however, be retested after a few weeks.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Animals -
- Antibodies, Anti-Idiotypic - immunology
- Antibody Specificity - immunology
- Arthropod Venoms - immunology
- Child - immunology
- Female - immunology
- Humans - immunology
- Hymenoptera - immunology
- Hypersensitivity - blood
- Immunoglobulin E - blood
- Insect Bites and Stings - immunology
- Male - immunology
- Middle Aged - immunology
- Time Factors - immunology
- Find related publications in this database (Keywords)
- Hymenoptera Venom
- Specific IgE
- Cap
- Anaphylaxis/Allergy