Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoenigl, M; Raggam, RB; Wagner, J; Valentin, T; Leitner, E; Seeber, K; Zollner-Schwetz, I; Krammer, W; Prüller, F; Grisold, AJ; Krause, R.
Diagnostic accuracy of soluble urokinase plasminogen activator receptor (suPAR) for prediction of bacteremia in patients with systemic inflammatory response syndrome.
Clin Biochem. 2013; 46(3):225-229
Doi: 10.1016/j.clinbiochem.2012.11.004
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Krause Robert
- Raggam Reinhard Bernd
- Co-Autor*innen der Med Uni Graz
- Grisold Andrea
- Leitner-Meyer Eva
- Prüller Florian
- Rabensteiner Jasmin
- Valentin Thomas
- Zollner-Schwetz Ines
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- Abstract:
- Soluble urokinase plasminogen activator receptor (suPAR) serum concentrations have recently been described to reflect the severity status of systemic inflammation. In this study, the diagnostic accuracy of suPAR, C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) to predict bacteremia in patients with systemic inflammatory response syndrome (SIRS) was compared. A total of 132 patients with SIRS were included. In 55 patients blood cultures had resulted positive (study group 1, Gram positive bacteria: Staphylococcus aureus and Streptococcus spp., n=15; study group 2, Gram-negative bacteria, n=40) and 77 patients had negative blood culture results (control group, n=77). Simultaneously with blood cultures suPAR, CRP, PCT, IL-6 and white blood count (WBC) were determined. SuPAR values were significantly higher in study group 1 (median 8.11; IQR 5.78-15.53; p=0.006) and study group 2 (median 9.62; IQR 6.52-11.74; p<0.001) when compared with the control group (median 5.65; IQR 4.30-7.83). ROC curve analysis revealed an AUC of 0.726 for suPAR in differentiating SIRS patients with bacteremia from those without. The biomarkers PCT and IL-6 showed comparable results. Regarding combinations of biomarkers multiplying suPAR, PCT and IL-6 was most promising and resulted in an AUC value of 0.804. Initial suPAR serum concentrations were significantly higher (p=0.028) in patients who died within 28 days than in those who survived. No significant difference was seen for PCT, IL-6 and CRP. In conclusion, suPAR, IL-6 and PCT may contribute to predicting bacteremia in SIRS patients. Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Area Under Curve -
- Bacteremia - diagnosis
- Biomarkers - blood
- C-Reactive Protein - analysis
- Calcitonin - blood
- Calcitonin Gene-Related Peptide -
- Case-Control Studies -
- Escherichia coli - isolation & purification
- Escherichia coli - pathogenicity
- Female -
- Gram-Negative Bacterial Infections - microbiology
- Gram-Negative Bacterial Infections - pathology
- Gram-Positive Bacterial Infections - microbiology
- Gram-Positive Bacterial Infections - pathology
- Humans -
- Interleukin-6 - blood
- Klebsiella - isolation & purification
- Klebsiella - pathogenicity
- Leukocyte Count - methods
- Male -
- Middle Aged -
- Predictive Value of Tests -
- Prospective Studies -
- Protein Precursors - blood
- ROC Curve -
- Receptors, Urokinase Plasminogen Activator - blood
- Reproducibility of Results -
- Sensitivity and Specificity -
- Staphylococcus aureus - isolation & purification
- Staphylococcus aureus - pathogenicity
- Systemic Inflammatory Response Syndrome - microbiology
- Systemic Inflammatory Response Syndrome - pathology
- Find related publications in this database (Keywords)
- suPAR
- Bacteremia
- SIRS
- PCT
- IL-6
- Diagnostic accuracy