Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brodmann, M; Hafner, F; Gary, T; Seinost, G; Pilger, E.
Impaired Endothelial-Dependent and Endothelium-Independent Vasodilatation in Patients With Thromboangiitis Obliterans.
Clin Appl Thromb Hemost. 2012; 19(1):33-36
Doi: 10.1177/1076029611435093
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- Führende Autor*innen der Med Uni Graz
- Brodmann Marianne
- Co-Autor*innen der Med Uni Graz
- Gary Thomas
- Hafner Franz
- Pilger Ernst
- Seinost Gerald
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- Abstract:
- Background: Endothelial dysfunction is the key process in the development of atherosclerosis. The aim of our study was to evaluate endothelial dysfunction measured by the noninvasive technique of Celermajer that plays a role in the pathogenesis of thrombangitis obliterans. Methods: A total of 36 patients with thrombangitiis obliterans ([TAO]; mean age 44.9 +/- 1.3 years) were compared with 30 healthy individuals (mean age 36.1 +/- 1.8 years). High frequency ultrasound was used to measure changes in response to reactive hyperemia (leading to flow-mediated endothelium-dependent dilatation) and in response to 0.4 mg sublingual nitroglycerin ([NTG]; leading to NTG-induced, endothelium-independent dilatation). Results: Patients with TAO showed a lower but statistically not significant flow-mediated dilatation and a statistically significant reduced NTG-induced vasodilatation than the control group. Conclusion: Our results suggest that both mechanisms play a role in patients with TAO, the endothelium-independent impaired vasodilatation even in a more significant way than the impaired endothelium-dependent vasodilatation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology
- Female -
- Humans -
- Hyperemia - pathology Hyperemia - physiopathology
- Male -
- Middle Aged -
- Thromboangiitis Obliterans - pathology Thromboangiitis Obliterans - physiopathology
- Vasodilation -
- Find related publications in this database (Keywords)
- endothelial dysfunction
- thrombangitis obliterans
- flow-mediated-endothelial dependent dilatation
- nitroglycerin
- nitroglycerin-induced endothelium independent vasodilatation