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Bretterklieber, A; Legat, FJ; Wolf, P; Hofer, A.
Retrospective long-term follow-up in patients with chronic palmoplantar dermatoses after good response to bath PUVA therapy.
J Dtsch Dermatol Ges. 2012; 10(11):814-818
Doi: 10.1111/j.1610-0387.2012.07975.x
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Bretterklieber Agnes
- Hofer Angelika
- Co-authors Med Uni Graz
- Legat Franz
- Wolf Peter
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- Abstract:
- Numerous studies have confirmed the short-term effectiveness of 8-methoxypsoralen bath PUVA therapy in patients with chronic palmoplantar dermatoses; however, little is known about long-term results. In this retrospective study we examined the long-term results in 79 patients (mean age: 48 years) with chronic palmoplantar dermatoses who were treated with bath PUVA three times a week over an 8-year period. A good clinical response (a reduction of more than 50% of the skin lesions) occurred after a mean of 23 treatments and a mean cumulative UVA dose of 39 J/cm(2) in 51 patients (65%). In 2007 a questionnaire was sent to these 51 patients to assess the long-term outcome. With bath PUVA treatment, the best results were found in patients with hyperkeratotic eczema (17/22; 77% good clinical response) followed by patients with palmoplantar psoriasis (26/41; 63%) and patients with dyshidrotic eczema (8/16; 50%). Thirty-four patients (67%) answered the questionnaire after a mean follow-up interval of 4.3 years (10-87 months). Among these patients, 36% reported an improved course of disease after PUVA therapy with reduced frequency and/or intensity of the skin rash, and 29% of patients reported continued complete clearance. 79% of our patients reported a long-term reduction in the use of topical corticosteroids during the follow-up period (mean: 4.3 years). In addition, 67% of patients reported a lasting improvement in quality of life. These data show that bath PUVA may have a long-term, beneficial influence on the course of disease in a majority of patients with recalcitrant chronic palmoplantar dermatoses. © The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin • JDDG • 1610-0379/2012.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Baths - statistics & numerical data
- Chronic Disease -
- Combined Modality Therapy - statistics & numerical data
- Eczema, Dyshidrotic - drug therapy
- Eczema, Dyshidrotic - epidemiology
- Eczema, Dyshidrotic - pathology
- Female -
- Follow-Up Studies -
- Furocoumarins - therapeutic use
- Furocoumarins - epidemiology
- Humans -
- Keratoderma, Palmoplantar - drug therapy
- Keratoderma, Palmoplantar - epidemiology
- Keratoderma, Palmoplantar - pathology
- Male -
- Middle Aged -
- PUVA Therapy -
- Prevalence -
- Radiation-Sensitizing Agents - therapeutic use
- Retrospective Studies -
- Risk Factors -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- dyshidrotic eczema
- PUVA therapy
- 8-methoxypsoralen
- psoriasis
- hyperkeratosis palmaris et plantaris
- smoking