Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wang, L; Song, Y; Manson, JE; Pilz, S; März, W; Michaëlsson, K; Lundqvist, A; Jassal, SK; Barrett-Connor, E; Zhang, C; Eaton, CB; May, HT; Anderson, JL; Sesso, HD.
Circulating 25-Hydroxy-Vitamin D and Risk of Cardiovascular Disease: A Meta-Analysis of Prospective Studies.
Circ Cardiovasc Qual Outcomes. 2012; 5(6):819-829
Doi: 10.1161/CIRCOUTCOMES.112.967604
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- Co-Autor*innen der Med Uni Graz
- März Winfried
- Pilz Stefan
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- Abstract:
- Background-Vitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear. Methods and Results-We searched MEDLINE and EMBASE from 1966 through February 2012 for prospective studies that assessed the association of 25(OH)-vitamin D concentrations with CVD risk. A total of 24 articles met our inclusion criteria, from which 19 independent studies with 6123 CVD cases in 65 994 participants were included for a meta-analysis. In a comparison of the lowest with the highest 25(OH)-vitamin D categories, the pooled relative risk was 1.52 (95% confidence interval, 1.30-1.77) for total CVD, 1.42 (95% confidence interval, 1.19-1.71) for CVD mortality, 1.38 (95% confidence interval, 1.21-1.57) for coronary heart disease, and 1.64 (95% confidence interval, 1.27-2.10) for stroke. These associations remained strong and significant when analyses were limited to studies that excluded participants with baseline CVD and were better controlled for season and confounding. We used a fractional polynomial spline regression analysis to assess the linearity of dose-response association between continuous 25(OH)-vitamin D and CVD risk. The CVD risk increased monotonically across decreasing 25(OH)-vitamin D below approximate to 60 nmol/L, with a relative risk of 1.03 (95% confidence interval, 1.00-1.06) per 25-nmol/L decrement in 25(OH)-vitamin D. Conclusions-This meta-analysis demonstrated a generally linear, inverse association between circulating 25(OH)-vitamin D ranging from 20 to 60 nmol/L and risk of CVD. Further research is needed to clarify the association of 25(OH)-vitamin D higher than 60 nmol/L with CVD risk and assess causality of the observed associations. (Circ Cardiovasc Qual Outcomes. 2012;5:819-829.)
- Find related publications in this database (using NLM MeSH Indexing)
- Biological Markers - blood
- Cardiovascular Diseases - blood
- Humans -
- Linear Models -
- Odds Ratio -
- Prognosis -
- Prospective Studies -
- Risk Assessment -
- Risk Factors -
- Vitamin D - analogs & derivatives
- Vitamin D Deficiency - blood
- Find related publications in this database (Keywords)
- 25-hydroxy-vitamin D
- cardiovascular disease
- meta-analysis
- prospective study