Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hajos, F; Stark, B; Hensler, S; Prassl, R; Mosgoeller, W.
Inhalable liposomal formulation for vasoactive intestinal peptide
Int J Pharm. 2008; 357(1-2):286-294
Doi: 10.1016/j.ijpharm.2008.01.046
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Prassl Ruth
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- Abstract:
- Inhalation of vasoactive intestinal peptide (VIP) was suggested as promising treatment option of various lung diseases like asthma and pulmonary hypertension. However, the medical use of peptides is limited by their short half-life due to rapid enzymatic degradation in the airways. For that reason, we recently developed unilamellar nano-sized VIP-loaded liposomes (VLL). Now we investigated their applicability for inhalation purposes. After nebulisation by a mouthpiece ventilation inhaler we found the particle size almost unaffected, being in a size range appropriate for bronchiolar deposition; we observed no peptide release due to nebulisation. The VIP release kinetics from VLL were tested by an ex vivo vasorelaxation model. Exposure to target organs revealed an immediate response, which was significantly retarded for VLL as compared to free VIP (p=0.001). Using vasorelaxation as endpoint, we observed a sustained release and an extended pharmacological effect compared to equimolar free VIP. The liposomes have the potential to improve VIP inhalation therapy by providing a "dispersible peptide depot" in the bronchi. Thereby, the release of VIP from liposomes may be triggered by exposure to cells, i.e. directly by ligand-receptor interactions.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Inhalation -
- Animals -
- Drug Carriers -
- Drug Delivery Systems -
- Drug Storage -
- Gastrointestinal Agents - administration and dosage Gastrointestinal Agents - pharmacokinetics
- Indicators and Reagents -
- Liposomes - chemistry
- Male -
- Muscle Relaxation - drug effects
- Muscle, Smooth, Vascular - drug effects
- Nebulizers and Vaporizers -
- Particle Size -
- Rats -
- Rats, Sprague-Dawley -
- Reproducibility of Results -
- Vasoactive Intestinal Peptide - administration and dosage Vasoactive Intestinal Peptide - pharmacokinetics
- Find related publications in this database (Keywords)
- nanomedicine
- liposome
- drug inhalation
- VIP inhalation