Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pabst, G; Zweytick, D; Prassl, R; Lohner, K.
Use of X-ray scattering to aid the design and delivery of membrane-active drugs
Eur Biophys J. 2012; 41(10):915-929
Doi: 10.1007/s00249-012-0821-9
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- Co-authors Med Uni Graz
- Prassl Ruth
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- Abstract:
- Biological membranes can be targets for compounds that either disrupt their barrier function or affect protein function via membrane-mediated processes. Biophysical studies on membrane-mimetic systems composed of membrane lipids have contributed substantially to our knowledge on the pertaining membrane physics and aid the development of membrane-specific drugs. Moreover, lipid membranes and, in particular, liposomes are convenient systems for drug delivery. We review some of our recent work that demonstrates the applicability of X-ray scattering to understanding the molecular mechanisms of drug-membrane interactions. In particular we focus on effects of anesthetics, sphingomyelinase, and antimicrobial peptides. We further discuss X-ray scattering as a quality-control tool for liposomal drug-delivery systems.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Membrane - chemistry
- Drug Design -
- Humans -
- Lipid Bilayers - chemistry
- Liposomes - chemistry
- Membrane Proteins - chemistry
- X-Ray Diffraction -
- Find related publications in this database (Keywords)
- Lipid bilayer
- Non-lamellar phases
- Micelles
- Liposomes
- Lipid-drug interactions
- Lipid-protein interactions