Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kump, PK; Högenauer, C; Wenzl, HH; Petritsch, W.
A case of opportunistic skin infection with Mycobacterium marinum during adalimumab treatment in a patient with Crohn's disease.
J Crohns Colitis. 2013; 7(1):e15-e18
Doi: 10.1016/j.crohns.2012.04.015
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Constantini-Kump Patrizia
- Petritsch Wolfgang
- Co-Autor*innen der Med Uni Graz
- Hoegenauer Christoph
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- Abstract:
- Opportunistic infections, especially reactivation with M. tuberculosis, are major complications during treatment with anti-TNF agents. Infections with atypical mycobacteria like Mycobacterium marinum are rare and tend to turn into a difficult and prolonged course due to delayed diagnosis. This is the first case of M. marinum infection during adalimumab therapy in a patient with Crohn's disease. The most important diagnostic step was a detailed medical history as PCR tested for M. tuberculosis and for atypical subspecies was false negative. Up to now a discontinuation of anti-TNF therapy has been recommended, however, there is no consensus about the reintroduction of biologicals after sufficient anti-infective therapy. In this patient anti-TNF therapy had to be reintroduced because of increasing activity with no relapse of M. marinum after a follow-up of 12 months. Copyright © 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adalimumab -
- Adult -
- Anti-Inflammatory Agents - adverse effects
- Anti-Inflammatory Agents - therapeutic use
- Antibodies, Monoclonal, Humanized - adverse effects
- Antibodies, Monoclonal, Humanized - therapeutic use
- Antitubercular Agents - therapeutic use
- Crohn Disease - complications
- Crohn Disease - drug therapy
- Humans -
- Male -
- Mycobacterium Infections, Nontuberculous - chemically induced
- Mycobacterium Infections, Nontuberculous - complications
- Mycobacterium Infections, Nontuberculous - drug therapy
- Mycobacterium marinum -
- Opportunistic Infections - chemically induced
- Opportunistic Infections - complications
- Opportunistic Infections - drug therapy
- Skin Diseases, Bacterial - chemically induced
- Skin Diseases, Bacterial - complications
- Skin Diseases, Bacterial - drug therapy
- Tumor Necrosis Factor-alpha - antagonists & inhibitors