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Halwachs-Baumann, G; Wilders-Truschnig, M; Desoye, G; Hahn, T; Kiesel, L; Klingel, K; Rieger, P; Jahn, G; Sinzger, C.
Human trophoblast cells are permissive to the complete replicative cycle of human cytomegalovirus.
J Virol. 1998; 72(9):7598-7602 Doi: 10.1128/JVI.72.9.7598-7602.1998 [OPEN ACCESS]
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Leading authors Med Uni Graz: Baumann Gabriele
Co-authors Med Uni Graz: Desoye Gernot; Hahn Tom; Truschnig-Wilders Martini
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Abstract:: Human trophoblast cells were permissively infected by human cytomegalovirus. The kinetics of viral immediate-early, early, and late gene expression was clearly delayed compared to that in fibroblasts. Productive infection was unequivocally proven by the detection of virion particles, infectious virus in trophoblast culture supernatant, and cell-to-cell spread of cytomegalovirus from infected trophoblasts to uninfected fibroblasts. These observations indicate that infected trophoblasts may be involved in maternofetal transmission of human cytomegalovirus.
Find related publications in this database (using NLM MeSH Indexing): Antigens, Viral - biosynthesis; Cells, Cultured -; Cytomegalovirus - growth and development Cytomegalovirus - physiology; Humans -; Trophoblasts - virology; Virus Replication -