Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Marsh, LM; Pfefferle, PI; Pinkenburg, O; Renz, H.
Maternal signals for progeny prevention against allergy and asthma.
Cell Mol Life Sci. 2011; 68(11): 1851-1862.
Doi: 10.1007/s00018-011-0644-3
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- Führende Autor*innen der Med Uni Graz
- Marsh Leigh
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- Abstract:
- Allergy and asthma are chronic inflammatory diseases which result from complex gene-environment interactions. Recent evidence indicates the importance of prenatal and postnatal developmental processes in terms of maturation of balanced immune responses. According to the current view, gene-environment interactions during a restricted time frame are responsible for programming of the immune system in favor of allergic immune mechanisms later in life. The interaction between genes and environment is complex and only partially understood; however, heritable epigenetic modifications including chemical additions in and alternative packaging of the DNA have been shown to play a crucial role in this context. Novel data indicate that epigenetic mechanisms contribute to the development of T-helper cell function. Environmental factors, including diesel exhaust particles (DEP), vitamins and tobacco smoke, operate through such mechanisms. Furthermore, the role of environmental microbes provides another and maybe even more important group of exogenous exposures which operates in this critical time frame.
- Find related publications in this database (using NLM MeSH Indexing)
- Asthma - immunology Asthma - prevention and control
- Female -
- Fetus - immunology
- Humans -
- Hypersensitivity - immunology Hypersensitivity - prevention and control
- Immunity, Innate -
- Models, Biological -
- Find related publications in this database (Keywords)
- Allergy
- Asthma
- Toll-like receptors
- Innate immune system
- Allergy protection
- Prenatal
- Animal model