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SHR Neuro Cancer Cardio Lipid Metab Microb
Korsatko, S; Glettler, K; Olsen, KJ; Wutte, A; Bock, G; Koehler, G; Mader, JK; Semlitsch, B; Pieber, TR.
A direct comparison of the pharmacodynamic properties of insulin detemir and neutral protamine lispro (NPL) insulin in patients with type 1 diabetes.
Diabetes Obes Metab. 2013; 15(3):241-245
Doi: 10.1111/dom.12016
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Korsatko Stefan
- Pieber Thomas
- Co-authors Med Uni Graz
- Köhler Gerd
- Mader Julia
- Semlitsch Barbara
- Treiber Gerlies
- Wutte Andrea-Maria
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- Abstract:
- Aims To compare the pharmacodynamic properties of insulin detemir (detemir) and neutral protamine lispro (NPL) insulin using a euglycaemic glucose clamp. Methods In a double-blind, crossover study, 30 patients with C-peptide negative type 1 diabetes were randomly assigned to a single dose (0.4 U/kg) of detemir and NPL. Plasma glucose (PG) was normalized with a variable insulin infusion and then decreased stepwise, followed by a euglycaemic clamp at 5.5 mmol/l over 32 h. Duration of action was defined as time from dosing until PG exceeded 8.3 mmol/l for at least 30 min. Results Duration of action was similar for detemir [23.0 (range 2.2532) h] and NPL [22.0 (9.532) h], p?=?0.55. Using glucose infusion rate (GIR) parameters, detemir showed a flatter pharmacodynamic profile versus NPL: area under the curve, AUCGIR(032)?=?1326 vs. 1841 mg/kg, p?
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Area Under Curve -
- Blood Glucose - drug effects Blood Glucose - metabolism
- Body Mass Index -
- Cross-Over Studies -
- Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy
- Dose-Response Relationship, Drug -
- Double-Blind Method -
- Female -
- Glucose Clamp Technique - methods
- Humans -
- Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology
- Insulin - administration & dosage Insulin - analogs & derivatives Insulin - pharmacology
- Insulin, Long-Acting - administration & dosage Insulin, Long-Acting - pharmacology
- Male -
- Protamines - administration & dosage Protamines - pharmacology
- Find related publications in this database (Keywords)
- insulin analogues
- insulin therapy
- pharmacodynamics
- randomized trial
- type 1 diabetes