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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Pilz, S; Marz, W; .
Vitamin D and cardiovascular diseases: where do we stand in 2012?.
LABORATORIUMSMEDIZIN. 2012; 36(5): 281-289. Doi: 10.1515/labmed-2011-0029
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Führende Autor*innen der Med Uni Graz: März Winfried; Pilz Stefan
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Abstract:: Evidence is accumulating that vitamin D may play a role in the pathogenesis of cardiovascular diseases. Vitamin D receptors (VDR) and enzymes of vitamin D metabolism are expressed in the vascular system and in the heart. VDR knockout mice suffer from cardiovascular disease (CVD) and selective inactivation of the VDR causes myocardial hypertrophy in cardiac myocytes. Many, but not all, observational studies have shown that vitamin D deficiency is associated with CVD and its risk factors. A low concentration of 25-hydroxyvitamin D (25 [OH] D) is an independent risk factor for CVD, stroke and sudden cardiac death. There are very few randomized controlled trials (RCTs) of the effects of vitamin D supplementation on cardiovascular endpoints, and conclusions can hardly be drawn as in some trials calcium has also been supplemented, which may increase the risk for CVD. Studies in which only vitamin D was given have indicated positive effects on cardiovascular risk factors, such as arterial hypertension. A number of larger studies of the effects of vitamin D supplementation on cardiovascular events and mortality have been undertaken. The design of these studies, however, may be problematic because, for example, individuals with high 25 (OH) D concentration also qualify for inclusion. The current body of evidence is not sufficient to recommend vitamin D supplementation for the prevention and treatment of CVD in general. Prevention and treatment of vitamin D deficiency, however, are both justified by the effects of vitamin D on the musculoskeletal system.
Find related publications in this database (Keywords): atherosclerosis; cerebrovascular insufficiency; heart failure; myocardial infarction; vitamin D