Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schoellnast, H; Monette, S; Ezell, PC; Maybody, M; Erinjeri, JP; Stubblefield, MD; Single, G; Solomon, SB.
The delayed effects of irreversible electroporation ablation on nerves.
Eur Radiol. 2013; 23(2):375-380
Doi: 10.1007/s00330-012-2610-3
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- Führende Autor*innen der Med Uni Graz
- Schoellnast Helmut
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- Abstract:
- To evaluate the delayed effects of irreversible electroporation (IRE) ablation on nerves. The study was approved by the institutional animal care and use committee. CT-guided IRE-ablation (electric field per distance, 1,500 V/cm; pulse length, 70 mu s; number of pulses, 90) of 6 sciatic nerves was performed in 6 pigs that were euthanized 2 months after ablation. The sciatic nerves were harvested immediately after euthanasia for histopathological evaluation. Sections from selected specimens were stained with haematoxylin and eosin (H&E), Masson's trichrome (MT) method for collagen, and immunohistochemistry was performed for S100 and neurofilaments (markers for Schwann cells and axons, respectively). All nerves showed a preserved endoneural architecture and presence of numerous small calibre axons associated with Schwann cell hyperplasia, consistent with axonal regeneration. A fibrous scar was observed in the adjacent muscle tissue, confirming ablation at the site examined. After IRE-ablation of nerves, the preservation of the architecture of the endoneurium and the proliferation of Schwann cells may enable axonal regeneration as demonstrated after 2 months in this study. aEuro cent Irreversible electroporation (IRE) offers promise for non-thermal tumour ablation. aEuro cent Preservation of endoneural architecture and proliferation of Schwann cells follow IRE-ablation. aEuro cent Preservation of architecture and proliferation of Schwann cells may enable axonal regeneration. aEuro cent Despite morphological regeneration, nerve function remains variable after 2 months.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biopsy, Needle -
- Catheter Ablation - adverse effects Catheter Ablation - methods
- Disease Models, Animal -
- Electroporation -
- Follow-Up Studies -
- Immunohistochemistry -
- Nerve Regeneration - physiology
- Neural Conduction - physiology
- Random Allocation -
- Risk Assessment -
- Sciatic Nerve - pathology Sciatic Nerve - surgery
- Sus scrofa -
- Swine -
- Time Factors -
- Find related publications in this database (Keywords)
- Athermal ablation
- Irreversible electroporation
- Sciatic nerve
- CT-guidance
- Animal study