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Schneider, NI; Zigeuner, R; Langner, C.
Small Cell Carcinoma of the Urinary Bladder: A Rare Tumor with Propensity for Hepatic Involvement.
Am J Med Sci. 2013; 345(2):155-157 Doi: 10.1097/MAJ.0b013e3182648759 (- Case Report)
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Leading authors Med Uni Graz: Langner Cord
Co-authors Med Uni Graz: Zigeuner Richard
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Abstract:: Small cell (neuroendocrine) carcinoma of the bladder is a rare entity, accounting for less than 1% of all bladder tumors. The authors report 2 new cases of the disease, both presenting with liver metastasis. In the first case, small cell carcinoma occurred in an 85-year-old woman as tumor recurrence of previous micropapillary carcinoma and urothelial carcinoma in situ, illustrating the common coexistence with conventional urothelial carcinoma. In the second case of a 58-year-old man, non-small cell tumor components were not observed. Accurate diagnosis of small cell carcinoma may be challenging. A panel of different antibodies, including neuron-specific enolase, chromogranin A, synaptophysin and CD56 (neural cell adhesion molecule) is recommended. In conclusion, small cell carcinoma represents a rare and aggressive form of bladder malignancy. As illustrated by the 2 cases and according to the literature review, the tumor shows a so far underrecognized propensity for hepatic involvement.
Find related publications in this database (using NLM MeSH Indexing): Aged, 80 and over -; Carcinoma, Small Cell - diagnosis Carcinoma, Small Cell - therapy; Female -; Humans -; Liver Neoplasms - diagnosis Liver Neoplasms - secondary Liver Neoplasms - therapy; Male -; Middle Aged -; Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - therapy
Find related publications in this database (Keywords): Small cell carcinoma; Urinary bladder; Liver metastasis; Neuroendocrine; Biomarker