Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Riedl, CC; Ponhold, L; Flory, D; Weber, M; Kroiss, R; Wagner, T; Fuchsjager, M; Helbich, TH.
Magnetic resonance imaging of the breast improves detection of invasive cancer, preinvasive cancer, and premalignant lesions during surveillance of women at high risk for breast cancer
CLIN CANCER RES. 2007; 13(20): 6144-6152.
Doi: 10.1158/1078-0432.CCR-07-1270
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- Co-Autor*innen der Med Uni Graz
- Fuchsjäger Michael
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- Abstract:
- Purpose: To assess the diagnostic accuracy of mammography, ultrasound, and magnetic resonance imaging (MRI) of the breast in the surveillance of women at high risk for breast cancer. Experimental Design: In this prospective comparison study, women at high risk for breast cancer were offered annual surveillance examinations, consisting of mammography, ultrasound, and MRI, at a single tertiary care breast center. The sensitivity and specificity of each modality was based on the histopathologic evaluation of suspicious findings from all modalities plus the detected interval cancers. Results: Three hundred and twenty-seven women underwent 672 complete imaging rounds. Of a total of 28 detected cancers, 14 were detected by mammography, 12 by ultrasound, and 24 by MRI, which resulted in sensitivities of 50%, 42.9%, and 85.7%, respectively (P < 0.01). MRI detected not only significantly more invasive but also significantly more preinvasive cancers (ductal carcinoma in situ). Mammography, ultrasound, and MRI led to 25, 26, and 101 false-positive findings, which resulted in specificities of 98%, 98%, and 92%, respectively (P < 0.05). Thirty-five (35%) of these false-positive findings were atypical ductal hyperplasias, lesions considered to be of premalignant character. Nine (26%) of those were detected by mammography, 2 (6 %) with ultrasound, and 32 (91 %) with MRI (P < 0.01). Conclusion: Our results show that MRI of the breast improves the detection of invasive cancers, preinvasive cancers, and premalignant lesions in a high-risk population and should therefore become an integral part of breast cancer surveillance in these patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Breast - pathology
- Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - pathology
- Cell Transformation, Neoplastic -
- Child -
- False Positive Reactions -
- Female -
- Germ-Line Mutation -
- Humans -
- Image Processing, Computer-Assisted -
- Magnetic Resonance Imaging - methods
- Mammography -
- Mass Screening -
- Middle Aged -
- Neoplasm Invasiveness -
- Prospective Studies -
- Risk -
- Sensitivity and Specificity -
- Treatment Outcome -