Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fuchsjaeger, MH; Flory, D; Reiner, CS; Rudas, M; Riedl, CC; Helbich, TH.
The negative predictive value of electrical impedance scanning in BI-RADS category IV breast lesions
INVEST RADIOL. 2005; 40(7): 478-485.
Doi: 10.1097/01.rli.0000167425.34577.d1
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Fuchsjäger Michael
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- Abstract:
- Objectives: We sought to prospectively assess the value of electrical impedance scanning (EIS) in discriminating benign from malignant lesions classified as BI-RADS category IV in mammography in comparison with ultrasound (US), with a special focus on negative prediction. Materials and Methods: EIS was performed on 128 BI-RADS category IV lesions in 121 women (mean, 51.8 years). The newly developed EIS software 2.67 calculates a BI-RADS-like level of suspicion (LOS) on a 5-grade scale. LOS 1, 2, and 3 were considered negative; LOS 4 and 5 were considered positive. Histopathologic results were obtained in all lesions. Results: Histology proved 37 lesions malignant, 91 benign. Sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of EIS compared with US were 94.6%, 74.7%, 80.5%, 60.3%, 97.1% versus 90.5%, 33.8%, 47.2%, 29.7%, 92.0%, respectively. In 43 lesions sized <= 10 mm, EIS demonstrated better sensitivity, specificity, accuracy, PPV, and NPV of 100%, 83.3%, 90.7%, 82.6%, and 100%, respectively. Although NPV was also high, US showed no sufficient results in 39 (30.5%) lesions because of microcalcifications. Receiver operating curve analysis revealed best results for a combined use of US and EIS. Conclusions: With a NPV of 97.1% of EIS in BI-RADS category IV breast lesions, a negative result in these lesions could be firm indication to manage them as BI-RADS-category III and refer patients for a 6-month short-interval follow-up rather than performing a biopsy. The best adjunctive diagnostic performance can be achieved by a combination of US and EIS. Costs and patient morbidity could be minimized.
- Find related publications in this database (using NLM MeSH Indexing)
- Breast - pathology
- Breast Neoplasms - diagnosis Breast Neoplasms - ultrasonography
- Diagnosis, Differential -
- Electric Impedance - diagnostic use
- Female -
- Humans -
- Middle Aged -
- Neoplasm Staging -
- Predictive Value of Tests -
- Prospective Studies -
- Sensitivity and Specificity -
- Ultrasonography, Mammary -
- Find related publications in this database (Keywords)
- breast
- breast cancer
- electrical impedance scanning
- mammography
- ultrasound