Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reiner, CS; Helbich, TH; Rudas, M; Ponhold, L; Riedl, CC; Kropf, N; Fuchsjäger, MH.
Can galactography-guided stereotactic, 11-gauge, vacuum-assisted breast biopsy of intraductal lesions serve as an alternative to surgical biopsy?
Eur Radiol. 2009; 19(12):2878-2885
Doi: 10.1007/s00330-009-1502-7
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- Führende Autor*innen der Med Uni Graz
- Fuchsjäger Michael
- Co-Autor*innen der Med Uni Graz
- Fuchsjäger Nina
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- Abstract:
- The purpose of this study was to determine the value of galactography-guided, stereotactic, vacuum-assisted breast biopsy (VABB) for the assessment of intraductal breast lesions and its potential as a therapeutic tool that could eliminate the need for surgical excision. Eighteen patients (median age 64 years, range 37-80) with nipple discharge and galactography-verified intraductal lesions underwent galactography-guided, stereotactic, 11-gauge VABB followed by surgery. Histopathology findings from VABB and subsequent surgery were compared. Underestimation and false-negative rates were assessed. After VABB, histopathology revealed invasive ductal carcinoma (IDC) in three (17%), ductal carcinoma in situ (DCIS) in six (33%), high-risk lesions in six (33%) and benign lesions in three (17%) cases. After surgical biopsy, histopathology confirmed the previously established diagnosis in 11 lesions (61%). The underestimation rate for high-risk lesions and DCIS was 50% (6/12). The false-negative rate was 7% (1/14). Histopathology examination after surgery showed that not a single lesion had been completely removed at VABB. Galactography-guided VABB is a feasible diagnostic tool. However, its value as a therapeutic procedure is limited because of the high number of underestimated and missed lesions and because of the histopathological detection of lesions' remnants in every case. Surgical excision should be the therapeutic gold standard in cases of pathological nipple discharge and galactography abnormalities.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biopsy, Fine-Needle - methods
- Breast Neoplasms - diagnosis Breast Neoplasms - surgery
- Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - surgery
- Female -
- Humans -
- Mammary Glands, Human - pathology
- Mammography - methods
- Middle Aged -
- Reproducibility of Results -
- Sensitivity and Specificity -
- Stereotaxic Techniques -
- Surgery, Computer-Assisted - methods
- Find related publications in this database (Keywords)
- Mammography
- Breast cancer
- Galactography
- Intraductal lesion
- Vacuum-assisted breast biopsy