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Selected Publication:
Beer, M; Landschutz, W; Meininger, M; Seyfarth, T; Viehrig, M; Sandstede, J; Pabst, T; Kenn, W; Horn, M; Harre, K; von Kienlin, M; Neubauer, S; Hahn, D.
Determination of absolute concentrations of cardiac high-energy phosphates using P-31-MR-spectroscopy and SLOOP in healthy and diseased myocardium.
Rofo. 1999; 171(1):65-68
Doi: 10.1055/s-1999-9896
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Beer Meinrad
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- Abstract:
- Purpose: A quantitative P-31-MR-spectroscopic technique was used to assess the energy metabolism in healthy and diseased myocardium. Methods: P-31-spectra were acquired on a 1.5 T scanner using a 3D-chemical shift imaging technique. Based on the anatomical information provided by H-1-images, SLOOP (Spatial Localization with Optimal Pointspread Function) allows to obtain spectra from defined compartments. With SLOOP a free voxel shape with adaption to anatomic structures, e.g. the myocardium, is possible. Absolute values for phosphocreatine (PCr) and adenosine triphosphate (ATP) were determined using an external standard. Results: P-31-spectra showed only minimal contamination by surrounding tissue. The standard deviation for the determined values of healthy volunteers was low. Compared to healthy volunteers, reduced PCr and ATP concentrations were seen for dilative cardiomyopathies and coronary artery disease and unchanged concentrations were observed for hypertensive heart disease. Conclusion: P-31-MR-spectroscopy with SLOOP allows a non-invasive, quantitative analysis of cardiac energy metabolism.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphate - analysis
- Cardiomyopathy, Dilated - metabolism
- Electrocardiography -
- Energy Metabolism -
- Humans -
- Hypertension - metabolism
- Hypertrophy, Left Ventricular - metabolism
- Magnetic Resonance Spectroscopy - instrumentation Magnetic Resonance Spectroscopy - methods
- Myocardial Ischemia - metabolism
- Myocardium - metabolism
- Phosphates - analysis
- Phosphocreatine - analysis
- Find related publications in this database (Keywords)
- nuclear magnetic resonance
- spectroscopy
- high energy phosphate
- quantitative measurements