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Selected Publication:
Beer, M; Buchner, S; Sandstede, J; Viehrig, M; Lipke, C; Krug, A; Kostler, H; Pabst, T; Kenn, W; Landschutz, W; von Kienlin, M; Harre, K; Neubauer, S; Hahn, D.
P-31-MR spectroscopy for the evaluation of energy metabolism in intact residual myocardium after acute myocardial infarction in humans
MAGMA. 2001; 13(2):70-75
Doi: 10.1016/S1352-8661(01)00130-2
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Beer Meinrad
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- Abstract:
- Objective: experimental studies have demonstrated that acute myocardial infarction (MI) alters energy metabolism even in non-infarcted adjacent tissue. In patients with subacute MI, the influence of the regional ischemic insult on energy metabolism of intact septal myocardium was analyzed using P-31-Magnetic resonance spectroscopy (MRS). Patients and Methods: in eight patients with wall motion abnormalities in the anterior wall P-31-spectra were obtained from non-infarcted adjacent septal myocardium, as well as infarcted anterior myocardium (voxel size 25 ccm each) 29 +/- 8 days after MI using a 3D-CST technique. Additionally, cardiac function was analyzed using breath-hold cine MRL MRI was repeated 6 months after revascularization to assess viability of infarcted segments. Eight age-matched healthy volunteers served as control group. Results: according to follow-up MRI 4/8 patients showed regional wall motion recovery. Here, PCr/ATP-ratios were not significantly reduced in intact septal myocardium as well as infarcted anterior myocardium compared to healthy volunteers (1.28 +/- 0.10 and 1.14 +/- 0.09 vs. 1.45 +/- 0.29). No recovery of regional function was detected in 4/8 patients with-therefore-nonviable anterior myocardium. PCr/ATP-ratios were significantly reduced in intact and infarcted myocardium compared with healthy volunteers as well as to patients with wall motion recovery (0.77 +/- 0.17 and 0.49 +/- 0.23; P < 0.05). Discussion: these preliminary results indicate that energy metabolism is reduced in patients with persisting wall motion abnormalities after myocardial infarction and revascularization in ischemically injured as well as in adjacent non-injured myocardium. (C) 2001 Elsevier Science B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Case-Control Studies -
- Female -
- Heart - physiology
- Humans -
- Magnetic Resonance Spectroscopy - methods
- Male -
- Middle Aged -
- Myocardial Infarction - diagnosis Myocardial Infarction - pathology
- Myocardium - metabolism Myocardium - pathology
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