Medizinische Universität Graz - Research portal
Selected Publication:
Beer, M; Viehrig, M; Seyfarth, T; Sandstede, J; Lipke, C; Pabst, T; Kenn, W; Harre, K; Horn, M; Landschutz, W; von Kienlin, M; Neubauer, S; Hahn, D.
Analysis of cardiac energy metabolism in valve disease using P-31-MR-spectroscopy
Radiologe. 2000; 40(2):162-167
Doi: 10.1007/s001170050026
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Beer Meinrad
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- Abstract:
- Purpose: Heart valve disease combined with left ventricular hypertrophy leads to derangements in cardiac energy metabolism, which can be detected non-invasively by P-31-MR-spectroscopy. The purpose of the present study was to examine whether the derangements in cardiac metabolism are reversible after surgical valve replacement. Patients and methods: 10 healthy volunteers and 10 patients with aortic stenosis (pressure gradients >60 mmHg) were included. For assessment of energy metabolism,P-31-MR spectra were obtained with a double oblique 3D-CSI technique (voxel size 25 cm(3)). In 5 of 10 patients,follow-up examination was performed 3 months after surgical valve replacement (SVR). Left ventricular (LV) function was analyzed by cine MRI. Results: Before SVR the myocardial phosphocreatine to adenosinetriphosphate (PCr-ATP) ratio was significantly (p=0.0002) reduced to 0.80+/-0.25 in patients compared to 1.65+/-0.21 in volunteers. 3 months after SVR, LV mass had significantly (p=0.04) decreased from 238+/-33 g to 206+/-47 g. At the same time a significant (p=0.04) increase of the PCr-ATP ratio from 0.80+/-0.25 to 1.28+/-0.22 was observed. A slight, but not significant, reduction of the phosphodiester ATP ratio was observed before SVR, with a trend towards normalization after SVR. Conclusions: After SVR, the deranged energy metabolism shows a trend towards normalization. Further follow-up is necessary to determine whether complete normalization of the energetic derangement can be observed over longer periods of time following SVR.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aortic Valve Stenosis - diagnosis Aortic Valve Stenosis - physiopathology Aortic Valve Stenosis - surgery
- Energy Metabolism - physiology
- Female -
- Heart Valve Prosthesis Implantation -
- Humans -
- Magnetic Resonance Imaging, Cine -
- Magnetic Resonance Spectroscopy -
- Male -
- Middle Aged -
- Myocardium - metabolism
- Phosphates - metabolism
- Postoperative Complications - diagnosis Postoperative Complications - physiopathology
- Reference Values -
- Treatment Outcome -
- Ventricular Function, Left - physiology
- Find related publications in this database (Keywords)
- valve disease
- valve replacement
- MR-imaging
- P-31-MR-spectroscopy
- energy metabolism