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Selected Publication:
Beer, M; Sandstede, J; Landschutz, W; Viehrig, M; Harre, K; Horn, M; Meininger, M; Pabst, T; Kenn, W; Haase, A; von Kienlin, M; Neubauer, S; Hahn, D.
Altered energy metabolism after myocardial infarction assessed by P-31-MR-spectroscopy in humans
Eur Radiol. 2000; 10(8):1323-1328
Doi: 10.1007/s003300000316
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- Abstract:
- The value of 31P-magnetic resonance spectroscopy (MRS) as a possible tool to distinguish viable from non-viable tissue after myocardial infarction was analysed in humans. Fifteen patients 3 weeks after anterior myocardial infarction were studied with breath-hold cine MRI and 3D-CSI MRS (1.5 T system). 31P-spectra were obtained from infarcted as well as non-infarcted myocardium (voxel size 25 cm3 each). Gold standard for viability was recovery of regional function, as determined by a control MRI 6 months after revascularization. Ten age-matched healthy volunteers served as control group. No significant difference was found between the phosphocreatine to adenosinetriphosphate (PCr/ ATP) ratio of volunteers (SD 1.72+/-0.31) and non-infarcted septal myocardium of patients. Cine MRI demonstrated recovery of regional function in 10 patients, i. e. 10 patients showed viable and 5 non-viable myocardium. In viable myocardium, the PCr/ATP ratio was 1.47+/-0.38 (non-significant vs volunteers; p>0.05). In the 5 patients with akinetic myocardium, PCr peaks could not be detected. Therefore, calculation of PCr/ATP ratios was not possible. However, a significant reduction of the ATP signal-to-noise ratio (SNR) was observed (2.92+/-0.73 vs 6.68+/-0.80; patients vs volunteers; p<0.05). The SNR of ATP of akinetic regions may predict recovery of function after revascularization in patients with myocardial infarction.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphate - metabolism
- Adult -
- Aged -
- Energy Metabolism - physiology
- Female -
- Humans -
- Image Processing, Computer-Assisted -
- Imaging, Three-Dimensional -
- Magnetic Resonance Imaging, Cine -
- Magnetic Resonance Spectroscopy -
- Male -
- Middle Aged -
- Myocardial Contraction - physiology
- Myocardial Infarction - diagnosis Myocardial Infarction - physiopathology
- Myocardium - metabolism
- Phosphocreatine - metabolism
- Reference Values -
- Tissue Survival - physiology
- Find related publications in this database (Keywords)
- heart
- ischaemia
- MR imaging
- MR spectroscopy
- high-energy phosphates