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Selected Publication:
Textor, Z; Beer, M; Anetseder, M; Kostler, H; Kagerbauer, E; Kenn, W; Hahn, D; Roewer, N.
Caffeine impairs intramuscular energy balance in patients susceptible to malignant hyperthermia
Muscle Nerve. 2003; 28(3):353-358
Doi: 10.1002/mus.10445
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Beer Meinrad
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- Abstract:
- Malignant hyperthermia (MH) is a metabolic myopathy with an abnormal release of calcium by the sarcoplasmic reticulum (SR), triggered by volatile anesthetics and succinylcholine. Similarly, caffeine enhances Ca(2+)release by the SR in vitro. In a prospective, randomized study, high-energy phosphates were studied by intramuscular 31-phosphorus magnetic resonance spectroscopy ((31)P-MRS) in 10 MH-susceptible (MHS) and 7 MH-nonsusceptible (MHN) subjects before and after injection of 0.5 ml caffeine (20 mM). Intramuscular energy balance, measured by the ratios of P(i)/PCr and P(i)/gamma-ATP, did not differ between MHS and MHN patients before and after intramuscular caffeine injection. However, within each group, P(i)/PCr and P(i)/gamma-ATP increased significantly only in the MHS group. Intramuscular caffeine injection seemed to impair the metabolic balance in MHS individuals. This may reflect a local calcium overload leading to consumption of high-energy phosphates and increase of inorganic phosphate. Intramuscular stimulation by caffeine and (31)P-MRS may provide a valuable tool to investigate MH-related metabolic disturbances.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Caffeine - diagnostic use
- Calcium - metabolism
- Calcium Signaling - drug effects Calcium Signaling - physiology
- Disease Susceptibility - metabolism Disease Susceptibility - physiopathology Disease Susceptibility - radionuclide imaging
- Female -
- Humans -
- Injections, Intramuscular -
- Magnetic Resonance Spectroscopy -
- Male -
- Malignant Hyperthermia - metabolism Malignant Hyperthermia - physiopathology Malignant Hyperthermia - radionuclide imaging
- Metabolic Diseases - metabolism Metabolic Diseases - physiopathology Metabolic Diseases - radionuclide imaging
- Middle Aged -
- Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology
- Muscular Diseases - metabolism Muscular Diseases - physiopathology Muscular Diseases - radionuclide imaging
- Oxidative Phosphorylation - drug effects
- Phosphocreatine - metabolism
- Phosphorus - metabolism
- Phosphorus Radioisotopes - diagnostic use
- Prospective Studies -
- Sex Factors -
- Find related publications in this database (Keywords)
- caffeine
- diagnosis
- energy metabolism
- malignant hyperthermia
- P-31-MRS