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von Kienlin, M; Beer, M; Greiser, A; Hahn, D; Harre, K; Kostler, H; Landschutz, W; Pabst, T; Sandstede, J; Neubauer, S.
Advances in human cardiac P-31-MR spectroscopy: SLOOP and clinical applications
J Magn Reson Imaging. 2001; 13(4):521-527 Doi: 10.1002/jmri.1074
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Co-authors Med Uni Graz: Beer Meinrad
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Abstract:: Phosphorus magnetic resonance spectroscopy (31P-MRS) has revealed a lot about the biochemistry of physiological and pathological processes in the heart. Nevertheless, until today, cardiac 31P-MRS has not had any clinical impact, albeit some pioneering studies demonstrated that 31P-MRS can indeed provide diagnostic information. In this paper, the development of techniques for human cardiac 31P-MRS over the past decade is reviewed, and the requirements for a reliable clinical measurement protocol are discussed. Spatial localization with optimal pointspread function (SLOOP) is a new method to achieve spatial localization and absolute quantitation. Its properties are detailed, and preliminary findings in patients with dilated cardiomyopathy or myocardial infarction are presented.
Find related publications in this database (using NLM MeSH Indexing): Heart Diseases - diagnosis; Humans -; Magnetic Resonance Spectroscopy - diagnostic use Magnetic Resonance Spectroscopy - methods; Phosphorus Isotopes - diagnostic use
Find related publications in this database (Keywords): cardiac MR spectroscopy; high-energy phosphates; SLOOP; spatial response function; absolute quantitation; dilated cardiomyopathy