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Kostler, H; Beer, M; Landschutz, W; Buchner, S; Sandstede, J; Pabst, T; Kenn, W; Neubauer, S; von Kienlin, M; Hahn, D.
P-31-MR spectroscopy of all regions of the human heart at 1.5T with acquisition-weighted chemical shift imaging.
Rofo. 2001; 173(12):1093-1098 Doi: 10.1055/s-2001-18888
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Co-authors Med Uni Graz: Beer Meinrad
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Abstract:: Aim: Aim of this study was to show whether or not acquisition-weighted chemical shift imaging (AW-CSI) allows the determination of PCr and ATP in the lateral and posterior wall of the human heart at 1.5T. Methods: 12 healthy volunteers were examined using a conventional chemical shift imaging (CSI) and an AW-CSI The sequences differed only in the number of repetitions for each point in Ic space. A hanning function was used as filter function leading to 7 repetitions in the center of the k space and 0 in the corners. Thus, AW-CSI had the same re-solution as the CSI sequence. The results for both sequences were analyzed using identically positioned voxels in the septal, anterior, lateral and posterior wall. Results: The determined averaged AW-CSI signal to noise ratios were higher for PCr by a factor of 1.3 and for ATP by 1.4 than those of CSI. The PCr/ATP ratios were higher by a factor of 1.2 - 1.3 and showed a smaller standard deviation in all locations for AW-CSI. The mean PCr/ ATP ratios determined by AW-CSI of septal, lateral and posterior wall were almost identical (1.72 - 1.76), while it was higher in the anterior wall (1.9). Conclusions: The reduced contamination in AW-CSI improves the signal to noise ratio and the determination of the PCr/ATP ratio in cardiac P-31 spectroscopy compared to CSI with the same resolution. The results in volunteers indicate that AW-CSI renders P-31 spectroscopy of the lateral and posterior wall of the human heart feasible for patient studies at 1.5T.
Find related publications in this database (using NLM MeSH Indexing): Adenosine Triphosphate - metabolism; Adult -; Energy Metabolism - physiology; Female -; Humans -; Image Processing, Computer-Assisted -; Imaging, Three-Dimensional -; Magnetic Resonance Imaging -; Magnetic Resonance Spectroscopy -; Male -; Phosphocreatine - metabolism; Reference Values -
Find related publications in this database (Keywords): heart MR spectroscopy; MR phosphorus studies; MR localization; MR spectroscopy 3-dimensional; MR k-space