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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hebestreit, H; Biko, J; Drozd, V; Demidchik, Y; Burkhardt, A; Trusen, A; Beer, M; Reiners, C.
Pulmonary fibrosis in youth treated with radioiodine for juvenile thyroid cancer and lung metastases after Chernobyl
Eur J Nucl Med Mol Imaging. 2011; 38(9):1683-1690
Doi: 10.1007/s00259-011-1841-x
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- Co-authors Med Uni Graz
- Beer Meinrad
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- Abstract:
- Purpose The objective of this project was to systematically determine the prevalence and consequences of pulmonary fibrosis in youth with thyroid carcinoma and lung metastases from Belarus who were treated with radioiodine (I-131). Methods A total of 69 patients treated for juvenile thyroid carcinoma and lung metastasis with I-131 were assessed. A group of 29 patients without lung metastases and prior I-131 treatment served as controls. The assessments included a CT scan of the lungs, extensive pulmonary function testing and an incremental cycle test to volitional fatigue with measurements of oxygen uptake ((V) over dotO(2)), oxygen saturation and alveolar-arterial difference in oxygen partial pressure (Delta aaO(2)). Results Five patients with lung metastases showed advanced pulmonary fibrosis on CT scans and also had poorer lung functions compared with the 62 patients with none or minor signs of fibrosis and the 29 controls. Furthermore, these five patients showed lower peak ((V) over dotO(2)), lower oxygen saturation at peak exercise and higher exercise Delta aaO(2). They were younger at the time of cancer diagnosis and had received chemotherapy more frequently than youth with pulmonary metastases who did not develop fibrosis. One of the five patients subsequently died from pulmonary fibrosis. Conclusion Following the Chernobyl catastrophe, about 7% of children treated with radioiodine for thyroid carcinoma and lung metastases displayed pulmonary fibrosis which was associated with functional impairments. Based on the characteristics of affected individuals, the number of radioiodine courses may have to be limited, especially in young children, and chemotherapy should be avoided.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Chernobyl Nuclear Accident -
- Child -
- Exercise Test -
- Female -
- Humans -
- Iodine Radioisotopes - adverse effects Iodine Radioisotopes - therapeutic use
- Lung Neoplasms - radiotherapy Lung Neoplasms - secondary
- Lung Volume Measurements -
- Male -
- Pulmonary Fibrosis - epidemiology Pulmonary Fibrosis - etiology Pulmonary Fibrosis - physiopathology Pulmonary Fibrosis - radiography
- Pulmonary Fibrosis - epidemiology
- Risk Factors -
- Thyroid Neoplasms - pathology Thyroid Neoplasms - radiotherapy
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- Radioactive fallout
- Exercise test
- Oncology
- Respiratory
- Radionuclide therapy