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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Ritter, CO; Wilke, A; Wichmann, T; Beer, M; Hahn, D; Kostler, H.
Comparison of Intravascular and Extracellular Contrast Media for Absolute Quantification of Myocardial Rest-Perfusion Using High-Resolution MRI
J Magn Reson Imaging. 2011; 33(5):1047-1051
Doi: 10.1002/jmri.22557
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- Beer Meinrad
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- Abstract:
- Purpose: To use the contrast agent gadofosveset for absolute quantification, of myocardial perfusion and compare it with gadobenate dimeglumine (Gd-BOPTA) using a high-resolution generalized autocalibrating partially parallel acquisition (GRAPPA) sequence. Materials and Methods: Ten healthy volunteers were examined twice at two different dates with a first-pass perfusion examination at rest using prebolus technique. We used a 1.5 T scanner and a 32 channel heart-array coil with a steady-state free precession (SSFP) true fast Imaging with steady state precession (trueFISP) GRAPPA sequence (acceleration-factor 3). Manual delineation of the myocardial contours was performed and absolute quantification was performed after baseline and contamination correction. At the first appointment, 1cc/4cc of the extracellular contrast agent Gd-BOPTA were administered, on the second date, 1cc/4cc of the blood pool contrast agent (CA) gadofosveset. At each date the examination was repeated after a 15-minute time interval. Results: Using gadofosveset perfusion the value (in cc/g/min) at rest was 0.66 +/- 0.25 (mean +/- standard deviation) for the first, end 0.55 +/- 0.24 for the second CA application; for Gd-BOPTA it was 0.62 +/- 0.25 and 0.45 +/- 0.23. No significant difference was found between the acquired perfusion values. The apparent mean residence time in the myocardium was 23 seconds for gadofosveset and 19.5 seconds for Gd-BOPTA. Neither signal-to-noise ratio (SNR) nor subjectively rated image contrast showed a significant difference. Conclusion: The application of gadofosveset for an absolute quantification of myocardial perfusion is possible. Yet the acquired perfusion values show no significant differences to those determined with Gd-BOPTA, maintained the same SNR and comparable perfusion values, and did not picture the expected concentration time-course for an intravasal CA in the first pass.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Calibration -
- Contrast Media - pharmacology
- Female -
- Gadolinium - pharmacology
- Humans -
- Image Processing, Computer-Assisted - methods
- Magnetic Resonance Imaging - methods
- Male -
- Myocardium - pathology
- Organometallic Compounds - pharmacology
- Perfusion -
- Time Factors -
- Find related publications in this database (Keywords)
- magnetic resonance tomography
- myocardial perfusion
- quantitative first pass perfusion
- intravasal contrast medium