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Selected Publication:
Beer, M; Schneider, C; Kostler, H; Buchner, S; Sandstede, J; Toyka, KV; Hahn, D.
Quantitative analysis of energy metabolism in human muscle using SLOOP P-31-MR-spectroscopy
Rofo. 2002; 174(5):573-578
Doi: 10.1055/s-2002-28273
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Beer Meinrad
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- Abstract:
- Objective: Energy metabolism is vital for regular muscle function. In humans, in-vivo analysis using P-31-MR-spectroscopy (MRS) is mostly restricted to semiquantitative parameters due to technical demands. We applied Spatial Localization with Optimal Pointspread Function (SLOOP) for quantification in human skeletal and cardiac muscle. Subjects/Methods: 10 healthy volunteers and 4 patients with myotonic dystrophy type I were examined using a 1.5 T system (Magnetom VISION) and chemical shift imaging (CSI) for data collection. Concentrations of PCr, ATP and P-i as well as PCr/ATP ratios were calculated by SLOOP. Results: Concentrations of PCr, ATP and Pi were 29.9 +/- 3.4, 7.1 +/- 0.9 and 5.7 +/- 1.2 [mmol/kg] in normal skeletal muscle, corresponding to previously published studies. Two of the patients with a duration of disease longer than 10 years and a pronounced muscle weakness showed a significant decrease of PCr and ATP in skeletal muscle below 10 and 5 mmol/kg. One of these patients had an additional reduction of PCr in cardiac muscle. Conclusions: With MRS and SLOOP, a more accurate quantitative assessment of metabolism is now available in skeletal and cardiac muscle. Longitudinal studies of larger patient groups will allow to better describe the metabolic disorder in muscle disease over time. Moreover, these techniques offer a new way to quantify treatment effects in future trials.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biopsy -
- Disease Progression -
- Energy Metabolism -
- Female -
- Humans -
- Magnetic Resonance Spectroscopy - instrumentation Magnetic Resonance Spectroscopy - methods
- Male -
- Muscle Weakness - metabolism
- Muscle, Skeletal - metabolism
- Myocardium - metabolism
- Myotonic Dystrophy - metabolism
- Reference Values -
- Find related publications in this database (Keywords)
- MR spectroscopy
- bioenergetics
- human skeletal muscle
- myotonic dystrophy
- cardiac involvement