Medizinische Universität Graz - Research portal
Selected Publication:
Sandstede, JJW; Beer, M; Lipke, C; Pabst, T; Kenn, W; Harre, K; Neubauer, S; Hahn, D.
Time course of contrast enhancement patterns after Gd-BOPTA in correlation to myocardial infarction and viability: A feasibility study
J Magn Reson Imaging. 2001; 14(6):789-794
Doi: 10.1002/jmri.10007
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Beer Meinrad
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- Abstract:
- Our objective was to analyze contrast enhancement patterns (CEP) and their time course after myocardial infarction (MI) following injection of Gd-BOPTA in correlation with recovery of regional function. Seven patients with subacute MI (18 +/- nine days) were examined before, as well as three and six (n = six) months after, revascularization of the infarct-related artery. Regional wall motion abnormalities were assessed by cine-MRI, and repetitive images of one representative slice were acquired up to 45 minutes after 0.05 mmol/kg Gd-BOPTA using a T1-w TSE-sequence. Two patients showed mid-wall/subendocardial, one patient subendocardial enhancement of MI associated with mechanical improvement after revascularization. Three patients without improvement revealed a mid-wall hypoenhanced zone within the first five minutes after injection, which was unchanged at follow-up. One patient with partial functional improvement showed transmural enhancement and a mid-wall hypoenhanced zone in adjacent areas. With this feasibility study, we concluded that mid-wall and/or subendocardial enhancement after Gd-BOPTA was associated with viable myocardium, whereas detection of microvascular obstruction correlating with scar formation is suggested by mid-wall hypoenhancement within the first five minutes after injection.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Contrast Media - pharmacokinetics
- Feasibility Studies -
- Female -
- Humans -
- Image Enhancement -
- Magnetic Resonance Imaging, Cine -
- Male -
- Meglumine - analogs and derivatives Meglumine - diagnostic use Meglumine - pharmacokinetics
- Middle Aged -
- Myocardial Infarction - diagnosis Myocardial Infarction - metabolism Myocardial Infarction - physiopathology
- Organometallic Compounds - diagnostic use Organometallic Compounds - pharmacokinetics
- Time Factors -
- Find related publications in this database (Keywords)
- cardiac imaging, MR
- contrast agents, myocardial viability
- myocaridal infarction
- heart ischemia
- MR contrast enhancement